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- W1862930219 endingPage "39" @default.
- W1862930219 startingPage "29" @default.
- W1862930219 abstract "Single nucleotide polymorphisms (SNPs) have been classically used for dissecting various human complex disorders using candidate gene studies. During the last decade, large scale SNP analysis, i.e. genome-wide association studies (GWAS) have provided an agnostic approach to identify possible genetic loci associated with heterogeneous disease such as cancer susceptibility, prognosis of survival or drug response. Further, the advent of new technologies, including microarray-based genotyping as well as high throughput next generation sequencing has opened new avenues for SNPs to be used in clinical practice. It is speculated that the utility of SNPs to understand the mechanisms, biology of variable drug response and ultimately treatment individualization based on the individual’s genome composition will be indispensable in the near future. In the current review, we discuss the advantages and disadvantages of the clinical utility of genetic variants in disease risk-prediction, prognosis, clinical outcome and pharmacogenomics. The lessons and challenges for the utility of SNP-based biomarkers are also discussed, including the need for additional functional validation studies." @default.
- W1862930219 created "2016-06-24" @default.
- W1862930219 creator A5043670175 @default.
- W1862930219 creator A5044100781 @default.
- W1862930219 creator A5091226776 @default.
- W1862930219 date "2015-09-23" @default.
- W1862930219 modified "2023-10-01" @default.
- W1862930219 title "Single nucleotide polymorphisms in clinics: Fantasy or reality for cancer?" @default.
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