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• W18630108 abstract "Research Article16 January 1995free access Involvement of p21ras distinguishes positive and negative selection in thymocytes. K.A. Swan K.A. Swan Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle 98195. Search for more papers by this author J. Alberola-Ila J. Alberola-Ila Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle 98195. Search for more papers by this author J.A. Gross J.A. Gross Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle 98195. Search for more papers by this author M.W. Appleby M.W. Appleby Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle 98195. Search for more papers by this author K.A. Forbush K.A. Forbush Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle 98195. Search for more papers by this author J.F. Thomas J.F. Thomas Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle 98195. Search for more papers by this author R.M. Perlmutter R.M. Perlmutter Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle 98195. Search for more papers by this author K.A. Swan K.A. Swan Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle 98195. Search for more papers by this author J. Alberola-Ila J. Alberola-Ila Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle 98195. Search for more papers by this author J.A. Gross J.A. Gross Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle 98195. Search for more papers by this author M.W. Appleby M.W. Appleby Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle 98195. Search for more papers by this author K.A. Forbush K.A. Forbush Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle 98195. Search for more papers by this author J.F. Thomas J.F. Thomas Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle 98195. Search for more papers by this author R.M. Perlmutter R.M. Perlmutter Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle 98195. Search for more papers by this author Author Information K.A. Swan1, J. Alberola-Ila1, J.A. Gross1, M.W. Appleby1, K.A. Forbush1, J.F. Thomas1 and R.M. Perlmutter1 1Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle 98195. The EMBO Journal (1995)14:276-285https://doi.org/10.1002/j.1460-2075.1995.tb07001.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Small molecular weight GTP binding proteins of the ras family have been implicated in signal transduction from the T cell antigen receptor (TCR). To test the importance of p21ras in the control of thymocyte development, we generated mice expressing a dominant-negative p21ras protein (H-rasN17) in T lineage cells under the control of the lck proximal promoter. Proliferation of thymocytes from lck-H-rasN17 mice in response to TCR stimulation was nearly completely blocked, confirming the importance of p21ras in mediating TCR-derived signals in mature CD4+8- or CD8+4- thymocytes. In contrast, some TCR-derived signals proceeded unimpaired in the CD4+8+ thymocytes of mice expressing dominant-negative p21ras. Analysis of thymocyte development in mice made doubly transgenic for the H-Y-specific TCR and lck-H-rasN17 demonstrated that antigen-specific negative selection occurs normally in the presence of p21H-rasN17. Superantigen-induced negative selection in vivo also proceeded unhindered in H-rasN17 thymocytes. In contrast, positive selection of thymocytes in the H-Y mice was severely compromised by the presence of p21H-rasN17. These observations demonstrate that positive and negative selection, two conceptually antithetical consequences of TCR stimulation, are biochemically distinguishable. Previous ArticleNext Article Volume 14Issue 21 January 1995In this issue RelatedDetailsLoading ..." @default.
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• W18630108 date "1995-01-01" @default.
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• W18630108 title "Involvement of p21ras distinguishes positive and negative selection in thymocytes." @default.
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• W18630108 doi "https://doi.org/10.1002/j.1460-2075.1995.tb07001.x" @default.

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