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• W1863019843 abstract "The cyclic GMP-gated cationic channels of vertebrate photoreceptors are essential for visual phototransduction. We have examined the developmental regulation of cGMP-gated channels in morphologically identified cones in the chick retina. Expression of cone-type cGMP-gated channel mRNA can be detected at embryonic day 6 (E6), but expression of functional channels, as accessed by patch-clamp recordings, cannot be detected until E8. Plasma membrane channels in embryonic cones have a high turnover rate because inhibition of protein synthesis or disruption of the Golgi apparatus causes an almost complete loss of functional cGMP-gated channels within 12 hr. Different subpopulations of cones begin to express functional channels at different developmental stages, but all cones express channels by E10. Expression of cGMP-gated channels in at least one cone subpopulation appears to require one or more soluble differentiation factors, which are presumably present in the normal microenvironment of the developing retina. Application of chick embryo extract (CEE), a rich source of trophic factors, causes marked stimulation of cGMP-gated channel expression in chick cones at E8, but not at E6. Inhibition of MAP kinase (Erk) signaling using PD98059, or inhibition of PI3 kinase signaling by LY294002, blocked the stimulatory effects of CEE on E8 cones. Several recombinant trophic factors were also tested, but none could mimic the stimulatory effects of CEE on channel expression. In summary, the developmental expression of cGMP-gated cationic channels in embryonic cones appears to be regulated by epigenetic factors. The ability of cones to respond to these epigenetic factors is also developmentally regulated." @default.
• W1863019843 created "2016-06-24" @default.
• W1863019843 creator A5038755274 @default.
• W1863019843 creator A5043062769 @default.
• W1863019843 creator A5076008495 @default.
• W1863019843 date "2001-01-01" @default.
• W1863019843 modified "2023-09-23" @default.
• W1863019843 title "Developmental Expression of Retinal Cone cGMP-Gated Channels: Evidence for Rapid Turnover and Trophic Regulation" @default.
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• W1863019843 doi "https://doi.org/10.1523/jneurosci.21-01-00221.2001" @default.
• W1863019843 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6762422" @default.
• W1863019843 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11150339" @default.
• W1863019843 hasPublicationYear "2001" @default.
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