Matches in SemOpenAlex for { <https://semopenalex.org/work/W1863093603> ?p ?o ?g. }
- W1863093603 endingPage "15872" @default.
- W1863093603 startingPage "15863" @default.
- W1863093603 abstract "This study comprehensively investigates the changing biodistribution of fluorescent-labelled polystyrene latex bead nanoparticles in a mouse model of inflammation. Since inflammation alters systemic circulatory properties, increases vessel permeability and modulates the immune system, we theorised that systemic inflammation would alter nanoparticle distribution within the body. This has implications for prospective nanocarrier-based therapies targeting inflammatory diseases. Low dose lipopolysaccharide (LPS), a bacterial endotoxin, was used to induce an inflammatory response, and 20 nm, 100 nm or 500 nm polystyrene nanoparticles were administered after 16 hours. HPLC analysis was used to accurately quantify nanoparticle retention by each vital organ, and tissue sections revealed the precise locations of nanoparticle deposition within key tissues. During inflammation, nanoparticles of all sizes redistributed, particularly to the marginal zones of the spleen. We found that LPS-induced inflammation induces splenic macrophage polarisation and alters leukocyte uptake of nanoparticles, with size-dependent effects. In addition, spleen vasculature becomes significantly more permeable following LPS treatment. We conclude that systemic inflammation affects nanoparticle distribution by multiple mechanisms, in a size dependent manner." @default.
- W1863093603 created "2016-06-24" @default.
- W1863093603 creator A5027490491 @default.
- W1863093603 creator A5049486470 @default.
- W1863093603 creator A5056989738 @default.
- W1863093603 creator A5060730811 @default.
- W1863093603 creator A5062645891 @default.
- W1863093603 creator A5064390595 @default.
- W1863093603 creator A5065102952 @default.
- W1863093603 creator A5068897692 @default.
- W1863093603 creator A5069028042 @default.
- W1863093603 creator A5072228476 @default.
- W1863093603 creator A5079260930 @default.
- W1863093603 date "2015-01-01" @default.
- W1863093603 modified "2023-09-27" @default.
- W1863093603 title "Nanoparticle distribution during systemic inflammation is size-dependent and organ-specific" @default.
- W1863093603 cites W1493775316 @default.
- W1863093603 cites W1542924087 @default.
- W1863093603 cites W1641628118 @default.
- W1863093603 cites W1787488447 @default.
- W1863093603 cites W1927734345 @default.
- W1863093603 cites W1965097716 @default.
- W1863093603 cites W1966962897 @default.
- W1863093603 cites W1974273543 @default.
- W1863093603 cites W1976041621 @default.
- W1863093603 cites W1982974605 @default.
- W1863093603 cites W1988924112 @default.
- W1863093603 cites W1989353157 @default.
- W1863093603 cites W1998836670 @default.
- W1863093603 cites W2001275711 @default.
- W1863093603 cites W2005082473 @default.
- W1863093603 cites W2008300958 @default.
- W1863093603 cites W2013593155 @default.
- W1863093603 cites W2031406458 @default.
- W1863093603 cites W2031411898 @default.
- W1863093603 cites W2034383333 @default.
- W1863093603 cites W2053591440 @default.
- W1863093603 cites W2055750901 @default.
- W1863093603 cites W2056879548 @default.
- W1863093603 cites W2062007574 @default.
- W1863093603 cites W2065961872 @default.
- W1863093603 cites W2070166910 @default.
- W1863093603 cites W2076447217 @default.
- W1863093603 cites W2078057254 @default.
- W1863093603 cites W2082990150 @default.
- W1863093603 cites W2084564904 @default.
- W1863093603 cites W2085614016 @default.
- W1863093603 cites W2092877053 @default.
- W1863093603 cites W2113972541 @default.
- W1863093603 cites W2126622563 @default.
- W1863093603 cites W2126719418 @default.
- W1863093603 cites W2135268358 @default.
- W1863093603 cites W2136270624 @default.
- W1863093603 cites W2141518860 @default.
- W1863093603 cites W2143986100 @default.
- W1863093603 cites W2170611521 @default.
- W1863093603 cites W2306367177 @default.
- W1863093603 cites W2629368404 @default.
- W1863093603 doi "https://doi.org/10.1039/c5nr03626g" @default.
- W1863093603 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26359216" @default.
- W1863093603 hasPublicationYear "2015" @default.
- W1863093603 type Work @default.
- W1863093603 sameAs 1863093603 @default.
- W1863093603 citedByCount "70" @default.
- W1863093603 countsByYear W18630936032015 @default.
- W1863093603 countsByYear W18630936032016 @default.
- W1863093603 countsByYear W18630936032017 @default.
- W1863093603 countsByYear W18630936032018 @default.
- W1863093603 countsByYear W18630936032019 @default.
- W1863093603 countsByYear W18630936032020 @default.
- W1863093603 countsByYear W18630936032021 @default.
- W1863093603 countsByYear W18630936032022 @default.
- W1863093603 countsByYear W18630936032023 @default.
- W1863093603 crossrefType "journal-article" @default.
- W1863093603 hasAuthorship W1863093603A5027490491 @default.
- W1863093603 hasAuthorship W1863093603A5049486470 @default.
- W1863093603 hasAuthorship W1863093603A5056989738 @default.
- W1863093603 hasAuthorship W1863093603A5060730811 @default.
- W1863093603 hasAuthorship W1863093603A5062645891 @default.
- W1863093603 hasAuthorship W1863093603A5064390595 @default.
- W1863093603 hasAuthorship W1863093603A5065102952 @default.
- W1863093603 hasAuthorship W1863093603A5068897692 @default.
- W1863093603 hasAuthorship W1863093603A5069028042 @default.
- W1863093603 hasAuthorship W1863093603A5072228476 @default.
- W1863093603 hasAuthorship W1863093603A5079260930 @default.
- W1863093603 hasConcept C12554922 @default.
- W1863093603 hasConcept C155672457 @default.
- W1863093603 hasConcept C171250308 @default.
- W1863093603 hasConcept C18150654 @default.
- W1863093603 hasConcept C185592680 @default.
- W1863093603 hasConcept C192562407 @default.
- W1863093603 hasConcept C202751555 @default.
- W1863093603 hasConcept C203014093 @default.
- W1863093603 hasConcept C2776252253 @default.
- W1863093603 hasConcept C2776914184 @default.
- W1863093603 hasConcept C2777807558 @default.
- W1863093603 hasConcept C2778754761 @default.
- W1863093603 hasConcept C2780931953 @default.