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• W1863149780 startingPage "839" @default.
• W1863149780 abstract "Background: Chlorpyrifos (CP) is an organophosphorus pesticide that induces oxidative stress through the production of free radicals and depletes intracellular antioxidant reserves. In this study, the efficacy of three antioxidants (melatonin, coenzyme Q 10 (CoQ 10 ), and vinpocetine) on alleviation of toxic effects of CP was evaluated. Materials and Methods: Cytotoxicity of CP, in the presence or absence of effective doses of melatonin, CoQ 10 , and vinpocetine, was determined in human peripheral blood lymphocytes after 72-h exposure. The levels of acetylcholinesterase (AChE) activity along with tumor necrosis factor α (TNF-α), as inflammatory index, were measured. Further, the viability and oxidative stress markers including cellular mitochondrial activity, cell death modes (apoptosis vs. necrosis), total antioxidant power (TAP), total thiol molecules (TTM), lipid peroxidation (LPO), and myeloperoxidase (MPO) activity were measured. Results: CoQ 10 and also the combination of the three antioxidants were the most notable in opposing toxicity of CP and led to increasing TAP and TTM; improvement of AChE activity; and lowering LPO, MPO, TNF-α, and apoptosis compared to CP alone. Conclusion: CP toxicity overwhelms the intracellular antioxidant defense mechanisms. Exogenous supplementation with antioxidants, such as the ones we have investigated, seems to be effective in the prevention of cytotoxicity of CP." @default.
• W1863149780 created "2016-06-24" @default.
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• W1863149780 date "2016-07-11" @default.
• W1863149780 modified "2023-09-24" @default.
• W1863149780 title "A mechanistic approach for modulation of chlorpyrifos-induced toxicity in human lymphocytes by melatonin, coenzyme Q₁₀, and vinpocetine" @default.
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• W1863149780 doi "https://doi.org/10.1177/0960327115607945" @default.
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