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• W1863292076 abstract "Jaakko Piitulainen Reconstruction of cranial bone defects with fiber-reinforced composite–bioactive glass implants From the University of Turku, Faculty of Medicine, Department of Otorhinolaryngology–Head and Neck Surgery and the Department of Biomaterials Science, Doctoral Programme of Clinical Investigation; and Turku University Hospital, Turku, Finland Annales Universitas Turkuensis Ser. D, Painosalama Oy – Turku, Finland 2015 A cranial bone defect may result after an operative treatment of trauma, infection, vascular insult, or tumor. New biomaterials for cranial bone defect reconstructions are needed for example to mimic the biomechanical properties and structure of cranial bone. A novel glass fiber-reinforced composite implant with bioactive glass particulates (FRC–BG, fiber-reinforced composite–bioactive glass) has osteointegrative potential in a preclinical setting. The aim of the first and second study was to investigate the functionality of a FRC–BG implant in the reconstruction of cranial bone defects. During the years 2007–2014, a prospective clinical trial was conducted in two tertiary level academic institutions (Turku University Hospital and Oulu University Hospital) to evaluate the treatment outcome in 35 patients that underwent a FRC–BG cranioplasty. The treatment outcome was good both in adult and pediatric patients. A number of conventional complications related to cranioplasty were observed. In the third study, a retrospective outcome evaluation of 100 cranioplasty procedures performed in Turku University Hospital between years 2002–2012 was conducted. The experimental fourth study was conducted to test the load-bearing capacity and fracture behavior of FRC–BG implants under static loading. The interconnective bars in the implant structure markedly increased the load-bearing capacity of the implant. A loading test did not demonstrate any protrusions of glass fibers or fiber cut. The fracture type was buckling and delamination. In this study, a postoperative complication requiring a reoperation or removal of the cranioplasty material was observed in one out of five cranioplasty patients. The treatment outcomes of cranioplasty performed with different synthetic materials did not show significant difference when compared with autograft. The FRC–BG implant was demonstrated to be safe and biocompatible biomaterial for large cranial bone defect reconstructions in adult and pediatric patients." @default.
• W1863292076 created "2016-06-24" @default.
• W1863292076 creator A5030283692 @default.
• W1863292076 date "2015-10-30" @default.
• W1863292076 modified "2023-09-26" @default.
• W1863292076 title "Reconstruction of cranial bone defects with fiber-reinforced composite–bioactive glass implants" @default.
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