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- W1863510689 abstract "Summary We have analysed the effect of RAD52 deletion in several aspects of the cell biology of Candida albicans . Cultures of rad52 Δ strains exhibited slow growth and contained abundant cells with a filamentous morphology. Filamentation with polarization of actin patches was accompanied by the induction of the hypha‐specific genes (HSG) ECE1 , HWP1 and HGC1 . However, filament formation occurred in the absence of the transcription factors Efg1 and Cph1, even though disruption of EFG1 prevented expression of HSG. Therefore, expression of HSG genes accompanies but is dispensable for rad52 Δ filamentation. However, deletion of adenylate cyclase severely impaired filamentation, this effect being largely reverted by the addition of exogenous cAMP. Filaments resembled elongated pseudohyphae, but some of them looked like true hyphae. Following depletion of Rad52, many cells arrested at the G2/M phase of the cell cycle with a single nucleus suggesting the early induction of the DNA‐damage checkpoint. Filaments formed later, preferentially from G2/M cells. The filamentation process was accompanied by the uncoupling of several landmark events of the cell cycle and was partially dependent on the action of the cell cycle modulator Swe1. Hyphae were still induced by serum, but a large number of rad52 cells myceliated in G2/M." @default.
- W1863510689 created "2016-06-24" @default.
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- W1863510689 date "2006-01-20" @default.
- W1863510689 modified "2023-10-16" @default.
- W1863510689 title "Rad52 depletion in<i>Candida albicans</i>triggers both the DNA-damage checkpoint and filamentation accompanied by but independent of expression of hypha-specific genes" @default.
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- W1863510689 doi "https://doi.org/10.1111/j.1365-2958.2005.05038.x" @default.
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