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- W1864088128 abstract "Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype that lacks estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) amplification. Due to the absence of these receptors, TNBC does not respond to traditional endocrine or HER2-targeted therapies that improve patient prognosis in other breast cancer subtypes. TNBC has a poor prognosis, and currently, there are no effective targeted therapies. Some TNBC tumors express androgen receptor (AR) and may benefit from AR-targeted therapies. Here, we review the literature on AR in TNBC and propose that TNBC be further sub-classified as either AR+ TNBC or quadruple negative breast cancer since targeting AR may represent a viable therapeutic option for a subset of TNBC." @default.
- W1864088128 created "2016-06-24" @default.
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- W1864088128 date "2015-07-23" @default.
- W1864088128 modified "2023-09-26" @default.
- W1864088128 title "Androgen Receptor Biology in Triple Negative Breast Cancer: a Case for Classification as AR+ or Quadruple Negative Disease" @default.
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- W1864088128 doi "https://doi.org/10.1007/s12672-015-0232-3" @default.
- W1864088128 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6897499" @default.
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