FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1864133704> ?p ?o ?g. }

• W1864133704 endingPage "423" @default.
• W1864133704 startingPage "415" @default.
• W1864133704 abstract "Background Angiotensin converting enzyme inhibitors (ACE-Is) and angiotensin receptor blockers (ARBs) are recommended in heart failure with reduced ejection fraction (HFREF), but there is limited data on ARB vs. ACE-I and their combination in unselected populations. The purpose of this study was to compare the associations between the use of ACE-I, ARB and their combination, and outcomes in HFREF. Methods and results We prospectively studied 22,947 patients with HFREF (ejection fraction < 40%) enrolled in the Swedish Heart Failure Registry who received ACE-I but not ARB (n = 15,801, 69%), ARB but not ACE-I (n = 4335, 19%), their combination (n = 571, 2%) or neither (n = 2240, 10%). As compared with ACE-I alone, the hazard ratios (HRs) for ARB alone for all-cause mortality was 0.97 (95% CI = 0.91–1.03; p = 0.27), for HF hospitalization 1.08 (CI = 1.02–1.15; p < 0.01) and for the composite outcome 1.03 (CI = 0.99–1.08; p = 0.15). ACE-I and ARB combination had for death HR = 0.98 (95% CI = 0.84–1.14; p = 0.76), for HF hospitalization HR = 1.49 (CI = 1.33–1.68; p < 0.01) and for the composite outcome HR = 1.35 (CI = 1.21–1.50; p < 0.01). Use of neither ACE-I nor ARB was associated with HR for death 1.41 (CI = 1.33–1.50; p < 0.01), for HF hospitalization 1.16 (CI = 1.08–1.25; p < 0.01) and for the composite outcome 1.28 (CI = 1.21–1.35; p < 0.01). Conclusion This large generalizable analysis confirms the current recommendation of using ACE-I as first choice in HFREF. ARB can be considered an alternative in patients who cannot use ACE-I but should not routinely replace ACE-I. The combination of ACE-I and ARB was not associated with additional benefit over either one alone, and may potentially be harmful." @default.
• W1864133704 created "2016-06-24" @default.
• W1864133704 creator A5015344056 @default.
• W1864133704 creator A5022157096 @default.
• W1864133704 creator A5067972379 @default.
• W1864133704 creator A5070855397 @default.
• W1864133704 creator A5073037854 @default.
• W1864133704 creator A5077462483 @default.
• W1864133704 creator A5084443221 @default.
• W1864133704 date "2015-11-01" @default.
• W1864133704 modified "2023-10-16" @default.
• W1864133704 title "Comparative associations between angiotensin converting enzyme inhibitors, angiotensin receptor blockers and their combination, and outcomes in patients with heart failure and reduced ejection fraction" @default.
• W1864133704 cites W1966912437 @default.
• W1864133704 cites W1968782440 @default.
• W1864133704 cites W2006408873 @default.
• W1864133704 cites W2014174704 @default.
• W1864133704 cites W2020860227 @default.
• W1864133704 cites W2021011733 @default.
• W1864133704 cites W2026750621 @default.
• W1864133704 cites W2043990618 @default.
• W1864133704 cites W2055123579 @default.
• W1864133704 cites W2056893352 @default.
• W1864133704 cites W2098780362 @default.
• W1864133704 cites W2100082183 @default.
• W1864133704 cites W2100767767 @default.
• W1864133704 cites W2114557145 @default.
• W1864133704 cites W2121859696 @default.
• W1864133704 cites W2144030911 @default.
• W1864133704 cites W2148910374 @default.
• W1864133704 cites W2152798629 @default.
• W1864133704 cites W2166018731 @default.
• W1864133704 cites W2168907840 @default.
• W1864133704 cites W2585382523 @default.
• W1864133704 cites W3021063182 @default.
• W1864133704 cites W4245244523 @default.
• W1864133704 cites W4293084779 @default.
• W1864133704 doi "https://doi.org/10.1016/j.ijcard.2015.07.051" @default.
• W1864133704 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26247798" @default.
• W1864133704 hasPublicationYear "2015" @default.
• W1864133704 type Work @default.
• W1864133704 sameAs 1864133704 @default.
• W1864133704 citedByCount "7" @default.
• W1864133704 countsByYear W18641337042017 @default.
• W1864133704 countsByYear W18641337042020 @default.
• W1864133704 countsByYear W18641337042021 @default.
• W1864133704 countsByYear W18641337042022 @default.
• W1864133704 crossrefType "journal-article" @default.
• W1864133704 hasAuthorship W1864133704A5015344056 @default.
• W1864133704 hasAuthorship W1864133704A5022157096 @default.
• W1864133704 hasAuthorship W1864133704A5067972379 @default.
• W1864133704 hasAuthorship W1864133704A5070855397 @default.
• W1864133704 hasAuthorship W1864133704A5073037854 @default.
• W1864133704 hasAuthorship W1864133704A5077462483 @default.
• W1864133704 hasAuthorship W1864133704A5084443221 @default.
• W1864133704 hasConcept C104849204 @default.
• W1864133704 hasConcept C126322002 @default.
• W1864133704 hasConcept C164705383 @default.
• W1864133704 hasConcept C170493617 @default.
• W1864133704 hasConcept C207103383 @default.
• W1864133704 hasConcept C27016395 @default.
• W1864133704 hasConcept C2778198053 @default.
• W1864133704 hasConcept C2779611605 @default.
• W1864133704 hasConcept C2908929049 @default.
• W1864133704 hasConcept C44249647 @default.
• W1864133704 hasConcept C71924100 @default.
• W1864133704 hasConcept C78085059 @default.
• W1864133704 hasConcept C84393581 @default.
• W1864133704 hasConceptScore W1864133704C104849204 @default.
• W1864133704 hasConceptScore W1864133704C126322002 @default.
• W1864133704 hasConceptScore W1864133704C164705383 @default.
• W1864133704 hasConceptScore W1864133704C170493617 @default.
• W1864133704 hasConceptScore W1864133704C207103383 @default.
• W1864133704 hasConceptScore W1864133704C27016395 @default.
• W1864133704 hasConceptScore W1864133704C2778198053 @default.
• W1864133704 hasConceptScore W1864133704C2779611605 @default.
• W1864133704 hasConceptScore W1864133704C2908929049 @default.
• W1864133704 hasConceptScore W1864133704C44249647 @default.
• W1864133704 hasConceptScore W1864133704C71924100 @default.
• W1864133704 hasConceptScore W1864133704C78085059 @default.
• W1864133704 hasConceptScore W1864133704C84393581 @default.
• W1864133704 hasFunder F4320322581 @default.
• W1864133704 hasLocation W18641337041 @default.
• W1864133704 hasLocation W18641337042 @default.
• W1864133704 hasOpenAccess W1864133704 @default.
• W1864133704 hasPrimaryLocation W18641337041 @default.
• W1864133704 hasRelatedWork W1991157605 @default.
• W1864133704 hasRelatedWork W1995604303 @default.
• W1864133704 hasRelatedWork W2022842708 @default.
• W1864133704 hasRelatedWork W2027472844 @default.
• W1864133704 hasRelatedWork W2048982602 @default.
• W1864133704 hasRelatedWork W2055306864 @default.
• W1864133704 hasRelatedWork W2060793623 @default.
• W1864133704 hasRelatedWork W2072625252 @default.
• W1864133704 hasRelatedWork W2093949391 @default.
• W1864133704 hasRelatedWork W2741586533 @default.
• W1864133704 hasVolume "199" @default.
• W1864133704 isParatext "false" @default.
• W1864133704 isRetracted "false" @default.

• next