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• W1864291299 abstract "Paraquat (PQ) and maneb (MB) are able to induce neurotoxic effects by promoting α-synuclein (α-syn) aggregates and altering tyrosine hydroxylase (TH), thus increasing the risk of Parkinson's disease (PD). These pesticides promote neurotoxic effects also by affecting proteasome function that normally regulate protein turnover. We investigated the effects of the two pesticides exposure on multiple targets involved in PD, using SH-SY5Y cells. First, we evaluated TH and α-syn protein levels following PQ and MB cell exposure and a significant increase of these protein levels was observed. Subsequently, since a relationship between ubiquitin/proteasome and opioid receptors has been proposed, the effects of pesticides on their gene expression have been investigated. A decrease of β1 and Rpt3 proteasome subunit mRNA levels, together with the μ and δ opioid receptor down-regulation, was detected. The reported alterations, here simultaneously observed, help to clarify the involvement of multiple biological markers implicated in PD, often separately evaluated." @default.
• W1864291299 created "2016-06-24" @default.
• W1864291299 creator A5005022924 @default.
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• W1864291299 creator A5025307452 @default.
• W1864291299 creator A5026540454 @default.
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• W1864291299 date "2015-11-01" @default.
• W1864291299 modified "2023-10-12" @default.
• W1864291299 title "Proteasome subunit and opioid receptor gene expression down-regulation induced by paraquat and maneb in human neuroblastoma SH-SY5Y cells" @default.
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• W1864291299 doi "https://doi.org/10.1016/j.etap.2015.09.019" @default.
• W1864291299 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26498265" @default.
• W1864291299 hasPublicationYear "2015" @default.
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