Matches in SemOpenAlex for { <https://semopenalex.org/work/W186444186> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W186444186 abstract "Magnolol, a major active constituent in herbal medicine, potently inhibits propofol glucuronidation in human liver microsomes, with inhibition constants in the nanomolar range. This study was conducted to investigate magnolol-induced inhibition of propofol glucuronidation in liver microsomes from Swiss-Hauschka mice, Sprague-Dawley rats, Chinese Bama pigs, and cynomolgus macaques. Results indicated that magnolol (10 μM) inhibited propofol glucuronidation in liver microsomes from Bama pigs and cynomolgus macaques but not in those from mice or rats. Data from liver microsomes from Bama pigs indicated a competitive inhibition mechanism, with a Ki of 1.7 μM. In contrast to that of pig liver microsomes, the inhibition of microsomes from cynomolgus macaques followed a noncompetitive mechanism, with a Ki of 3.4 μM. In summary, this study indicates that magnolol-induced inhibition of propofol glucuronidation varies substantially among species, and the Ki values determined by using liver microsomes from various experimental animal species far exceed that for human liver microsomes. The inhibition of propofol glucuronidation by magnolol in liver microsomes from all animal species tested was significantly lower than the inhibition previously demonstrated in human liver microsomes. Hepatic microsomes from Swiss-Hauschka mice, Sprague-Dawley rats, Chinese Bama pigs, and cynomolgus macaques are not effective models of the inhibition of glucuronidation induced by magnolol in humans." @default.
- W186444186 created "2016-06-24" @default.
- W186444186 creator A5000316217 @default.
- W186444186 creator A5004745722 @default.
- W186444186 creator A5010664971 @default.
- W186444186 creator A5015282914 @default.
- W186444186 creator A5029111102 @default.
- W186444186 creator A5033431901 @default.
- W186444186 creator A5043073852 @default.
- W186444186 creator A5046454314 @default.
- W186444186 creator A5064507823 @default.
- W186444186 date "2014-07-01" @default.
- W186444186 modified "2023-09-27" @default.
- W186444186 title "Species-associated differences in the inhibition of propofol glucuronidation by magnolol." @default.
- W186444186 cites W1970221032 @default.
- W186444186 cites W1972889265 @default.
- W186444186 cites W2013178687 @default.
- W186444186 cites W2026081541 @default.
- W186444186 cites W2037744796 @default.
- W186444186 cites W2039044787 @default.
- W186444186 cites W2064939336 @default.
- W186444186 cites W2069818459 @default.
- W186444186 cites W2098008269 @default.
- W186444186 cites W2104334080 @default.
- W186444186 cites W2104965603 @default.
- W186444186 cites W2137865581 @default.
- W186444186 cites W2144266807 @default.
- W186444186 cites W2146850374 @default.
- W186444186 cites W2148633929 @default.
- W186444186 cites W2150544730 @default.
- W186444186 cites W2159914374 @default.
- W186444186 cites W2324476399 @default.
- W186444186 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4113243" @default.
- W186444186 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25199099" @default.
- W186444186 hasPublicationYear "2014" @default.
- W186444186 type Work @default.
- W186444186 sameAs 186444186 @default.
- W186444186 citedByCount "2" @default.
- W186444186 countsByYear W1864441862018 @default.
- W186444186 countsByYear W1864441862019 @default.
- W186444186 crossrefType "journal-article" @default.
- W186444186 hasAuthorship W186444186A5000316217 @default.
- W186444186 hasAuthorship W186444186A5004745722 @default.
- W186444186 hasAuthorship W186444186A5010664971 @default.
- W186444186 hasAuthorship W186444186A5015282914 @default.
- W186444186 hasAuthorship W186444186A5029111102 @default.
- W186444186 hasAuthorship W186444186A5033431901 @default.
- W186444186 hasAuthorship W186444186A5043073852 @default.
- W186444186 hasAuthorship W186444186A5046454314 @default.
- W186444186 hasAuthorship W186444186A5064507823 @default.
- W186444186 hasConcept C181199279 @default.
- W186444186 hasConcept C185592680 @default.
- W186444186 hasConcept C2776277131 @default.
- W186444186 hasConcept C2776524530 @default.
- W186444186 hasConcept C2779907587 @default.
- W186444186 hasConcept C2781009524 @default.
- W186444186 hasConcept C55493867 @default.
- W186444186 hasConcept C86803240 @default.
- W186444186 hasConcept C87644729 @default.
- W186444186 hasConcept C98274493 @default.
- W186444186 hasConceptScore W186444186C181199279 @default.
- W186444186 hasConceptScore W186444186C185592680 @default.
- W186444186 hasConceptScore W186444186C2776277131 @default.
- W186444186 hasConceptScore W186444186C2776524530 @default.
- W186444186 hasConceptScore W186444186C2779907587 @default.
- W186444186 hasConceptScore W186444186C2781009524 @default.
- W186444186 hasConceptScore W186444186C55493867 @default.
- W186444186 hasConceptScore W186444186C86803240 @default.
- W186444186 hasConceptScore W186444186C87644729 @default.
- W186444186 hasConceptScore W186444186C98274493 @default.
- W186444186 hasLocation W1864441861 @default.
- W186444186 hasOpenAccess W186444186 @default.
- W186444186 hasPrimaryLocation W1864441861 @default.
- W186444186 hasRelatedWork W1883696469 @default.
- W186444186 hasRelatedWork W1945803568 @default.
- W186444186 hasRelatedWork W1964542437 @default.
- W186444186 hasRelatedWork W1979251035 @default.
- W186444186 hasRelatedWork W1989316030 @default.
- W186444186 hasRelatedWork W1997758801 @default.
- W186444186 hasRelatedWork W2025611744 @default.
- W186444186 hasRelatedWork W2045746441 @default.
- W186444186 hasRelatedWork W2090753188 @default.
- W186444186 hasRelatedWork W2135758343 @default.
- W186444186 hasRelatedWork W2147753513 @default.
- W186444186 hasRelatedWork W2150048612 @default.
- W186444186 hasRelatedWork W2171684539 @default.
- W186444186 hasRelatedWork W2196711258 @default.
- W186444186 hasRelatedWork W2320275776 @default.
- W186444186 hasRelatedWork W2407673810 @default.
- W186444186 hasRelatedWork W2412720138 @default.
- W186444186 hasRelatedWork W2769815100 @default.
- W186444186 hasRelatedWork W2883301548 @default.
- W186444186 hasRelatedWork W2947674368 @default.
- W186444186 isParatext "false" @default.
- W186444186 isRetracted "false" @default.
- W186444186 magId "186444186" @default.
- W186444186 workType "article" @default.