FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1864517042> ?p ?o ?g. }

• W1864517042 endingPage "1066" @default.
• W1864517042 startingPage "1052" @default.
• W1864517042 abstract "Increase in intracellular calcium ([Ca2+]i) is a key mediator of astrocyte signaling, important for activation of the calcineurin (CN)/nuclear factor of activated T cells (NFAT) pathway, a central mediator of inflammatory events. We analyzed the expression of matrix metalloproteinase 3 (Mmp3) in response to increases in [Ca2+]i and the role of the CN/NFAT pathway in this regulation. Astrocyte Mmp3 expression was induced by overexpression of a constitutively active form of NFATc3, whereas other MMPs and tissue inhibitor of metalloproteinases (TIMP) were unaffected. Mmp3 mRNA and protein expression was also induced by calcium ionophore (Io) and 2′(3′)-O-(4-benzoylbenzoyl) adenosine 5′-triphosphate (Bz-ATP) and Mmp3 upregulation was prevented by the CN inhibitor cyclosporin A (CsA). Ca2+-dependent astrocyte Mmp3 expression was also inhibited by actinomycin D, and a Mmp3 promoter luciferase reporter was efficiently activated by increased [Ca2+]i, indicating regulation at the transcriptional level. Furthermore, Ca2+/CN/NFAT dependent Mmp3 expression was confirmed in pure astrocyte cultures derived from neural stem cells (Ast-NSC), demonstrating that the induced Mmp3 expression occurs in astrocytes, and not microglial cells. In an in vivo stab-wound model of brain injury, MMP3 expression was detected in NFATc3-positive scar-forming astrocytes. Because [Ca2+]i increase is an early event in most brain injuries, these data support an important role for Ca2+/CN/NFAT-induced astrocyte MMP3 expression in the early neuroinflammatory response. Understanding the molecular pathways involved in this regulation could provide novel therapeutic targets and approaches to promoting recovery of the injured brain." @default.
• W1864517042 created "2016-06-24" @default.
• W1864517042 creator A5015102352 @default.
• W1864517042 creator A5015743312 @default.
• W1864517042 creator A5024269778 @default.
• W1864517042 creator A5030978055 @default.
• W1864517042 creator A5038786183 @default.
• W1864517042 creator A5088583259 @default.
• W1864517042 date "2013-04-26" @default.
• W1864517042 modified "2023-09-27" @default.
• W1864517042 title "NFATc3 promotes Ca²⁺-dependent MMP3 expression in astroglial cells" @default.
• W1864517042 cites W1482195692 @default.
• W1864517042 cites W1488829562 @default.
• W1864517042 cites W1491598928 @default.
• W1864517042 cites W1545558771 @default.
• W1864517042 cites W1571912743 @default.
• W1864517042 cites W1606314433 @default.
• W1864517042 cites W1633066991 @default.
• W1864517042 cites W1877235802 @default.
• W1864517042 cites W1924772544 @default.
• W1864517042 cites W1955881853 @default.
• W1864517042 cites W1965533650 @default.
• W1864517042 cites W1965769122 @default.
• W1864517042 cites W1966010049 @default.
• W1864517042 cites W1970641162 @default.
• W1864517042 cites W1970881264 @default.
• W1864517042 cites W1971029155 @default.
• W1864517042 cites W1972223063 @default.
• W1864517042 cites W1974105812 @default.
• W1864517042 cites W1978053309 @default.
• W1864517042 cites W1978535726 @default.
• W1864517042 cites W1984754431 @default.
• W1864517042 cites W1984899161 @default.
• W1864517042 cites W1988278010 @default.
• W1864517042 cites W1990461254 @default.
• W1864517042 cites W1993962367 @default.
• W1864517042 cites W1998557118 @default.
• W1864517042 cites W1999834041 @default.
• W1864517042 cites W2006289803 @default.
• W1864517042 cites W2007598101 @default.
• W1864517042 cites W2011553901 @default.
• W1864517042 cites W2012052743 @default.
• W1864517042 cites W2015627246 @default.
• W1864517042 cites W2016628803 @default.
• W1864517042 cites W2018225482 @default.
• W1864517042 cites W2020013726 @default.
• W1864517042 cites W2022469979 @default.
• W1864517042 cites W2022893410 @default.
• W1864517042 cites W2025022118 @default.
• W1864517042 cites W2033567679 @default.
• W1864517042 cites W2044038155 @default.
• W1864517042 cites W2050777200 @default.
• W1864517042 cites W2051259034 @default.
• W1864517042 cites W2052112599 @default.
• W1864517042 cites W2054986774 @default.
• W1864517042 cites W2058830580 @default.
• W1864517042 cites W2062975615 @default.
• W1864517042 cites W2066520425 @default.
• W1864517042 cites W2067244940 @default.
• W1864517042 cites W2069951758 @default.
• W1864517042 cites W2073880678 @default.
• W1864517042 cites W2076798789 @default.
• W1864517042 cites W2077445136 @default.
• W1864517042 cites W2078480515 @default.
• W1864517042 cites W2079356804 @default.
• W1864517042 cites W2079733602 @default.
• W1864517042 cites W2085434027 @default.
• W1864517042 cites W2088590766 @default.
• W1864517042 cites W2090459889 @default.
• W1864517042 cites W2090956512 @default.
• W1864517042 cites W2098888270 @default.
• W1864517042 cites W2105028929 @default.
• W1864517042 cites W2107277218 @default.
• W1864517042 cites W2109887761 @default.
• W1864517042 cites W2115097918 @default.
• W1864517042 cites W2121476655 @default.
• W1864517042 cites W2123630494 @default.
• W1864517042 cites W2133896679 @default.
• W1864517042 cites W2138406651 @default.
• W1864517042 cites W2149674371 @default.
• W1864517042 cites W2151846085 @default.
• W1864517042 cites W2162639406 @default.
• W1864517042 cites W2217293243 @default.
• W1864517042 doi "https://doi.org/10.1002/glia.22494" @default.
• W1864517042 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23625833" @default.
• W1864517042 hasPublicationYear "2013" @default.
• W1864517042 type Work @default.
• W1864517042 sameAs 1864517042 @default.
• W1864517042 citedByCount "26" @default.
• W1864517042 countsByYear W18645170422013 @default.
• W1864517042 countsByYear W18645170422014 @default.
• W1864517042 countsByYear W18645170422015 @default.
• W1864517042 countsByYear W18645170422016 @default.
• W1864517042 countsByYear W18645170422017 @default.
• W1864517042 countsByYear W18645170422018 @default.
• W1864517042 countsByYear W18645170422019 @default.
• W1864517042 countsByYear W18645170422021 @default.
• W1864517042 crossrefType "journal-article" @default.

• next