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- W186460574 abstract "This chapter discusses the composition and possible physiologic role of the thyroid lipids. The follicular epithelium and the colloid of the thyroid gland contain abundant material with affinity for lipid stains. Lipids are also found in the interalveolar tissue and can be extracted in large amounts from normal and abnormal thyroid tissue. They can act as iodide carriers, contribute to the pathogenesis of Hashimoto's disease and of certain forms of goiter, or serve as substrates and regulators of thyroid metabolism. In normal thyroid slices, free fatty acids (FFA) are oxidized actively even in the presence of glucose, which becomes the preferred substrate only when thyroid slices are incubated in a medium containing thyroid stimulating hormone. Under these conditions, glucose and FFA are utilized in part as a calorigenic source, in part for the synthesis of lipids, and in particular of phospholipids. Cholesterol biosynthesis, functioning as an irreversible trap for acetyl-CoA, can serve as a key regulator of metabolic pathways." @default.
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- W186460574 date "1974-01-01" @default.
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- W186460574 title "The Composition and Possible Physiologic Role of the Thyroid Lipids1 1This work was aided by Grants No. AM06034 and No. RR05641 from the National Institute of Arthritis and Metabolic Diseases, USPHS." @default.
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- W186460574 doi "https://doi.org/10.1016/b978-0-12-024912-1.50012-0" @default.
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