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- W1864759872 abstract "Previous reports demonstrated that the expression of thrombomodulin (TM) in endothelial cells was modulated by various agents. Although TM was down-regulated by endotoxin or cytokines, up-regulation of TM was accomplished when endothelial cells were stimulated with unphysiologically high concentrations of cyclic AMP derivatives or tumour-promoting phorbol esters. We investigated the expression of TM in human umbilical-vein endothelial cells (HUVECs) by physiological substances that can be released into the bloodstream. Histamine (0.1-10 microM, 1-48 h) increased TM activity, TM antigen in cell lysates and TM mRNA levels, but 5-hydroxytryptamine and bradykinin had no effect. Enhancement of TM activity by histamine was completely blocked by the H1-selective antagonist pyrilamine, whereas the H2-antagonist cimetidine had no effect, showing that histamine up-regulates TM activity via H1-receptors on HUVECs. Enhanced TM activity by histamine and the resultant increase in protein C activation might play a role in a feedback regulation for prevention of vascular thrombosis." @default.
- W1864759872 created "2016-06-24" @default.
- W1864759872 creator A5026835818 @default.
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- W1864759872 date "1991-06-15" @default.
- W1864759872 modified "2023-10-16" @default.
- W1864759872 title "Up-regulation of thrombomodulin by activation of histamine H1-receptors in human umbilical-vein endothelial cells <i>in vitro</i>" @default.
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- W1864759872 doi "https://doi.org/10.1042/bj2760739" @default.
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