FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1865227921> ?p ?o ?g. }

• W1865227921 endingPage "265" @default.
• W1865227921 startingPage "254" @default.
• W1865227921 abstract "Despite garnering high interest in fish nutrition as an essential amino acid in a number of teleosts, the metabolic and physiological functions of taurine remain poorly described in fish. This study describes the postprandial changes of taurine in Florida pompano juveniles fed a taurine-replete diet, followed by a wide screening of metabolic and physiological markers when fed a taurine-deficient diet over 16 days. The goal was to screen for markers of early taurine deficiency and identify its initial components. Postprandial taurine levels varied between 106.75 and 170.37 μg/ml with a mild peak at 2–4 h after feeding, and decreased to 72.1% of the baseline value at 6 h. Fish fed the taurine-deficient diet did not have reduced hematocrit or increased bilirubin, suggesting an absence of hemolysis. However, linear decreases in alkaline phosphatase activity and in bile acid content were observed (R2 = 0.5968 and 0.5613, respectively, P < 0.005). Filet composition showed an overall linear increase in moisture (R2 = 0.2666, P = 0.0338) and a marked, linear loss in lipid over time (R2 = 0.4059, P = 0.0059). There was also a drastic, quadratic decrease in all amino acid content of the liver (R2 > 0.75, P < 0.0001), which had decreased by 40% by day 16. Notably, levels of taurine, hydroxylysine and hydroxyproline sharply decreased and remained low. In the filet however, levels of most amino acids were not affected, except for hydroxyproline, hydroxylysine, proline, and glycine, whose levels increased significantly by day 16 while taurine levels had decreased. Serum levels were variable, and no pattern of change could be identified. Liver histology revealed marked vacuolation of hepatocytes and significant glycogen accumulation. Finally, hepatic mitochondrial proteins quadratically decreased with time (R2 = 0.6218, P = 0.0007), paralleled with a severe linear decrease in cytochrome c oxidase (COX) specific activity (R2 = 0.5940, P = 0.0002). This indicates that the mitochondrial electron transport chain was greatly disrupted, and which resulted in poor hepatic metabolism and production of oxidative radicals. In summary, the present study describes the first screening for metabolic and physiological biomarkers of early taurine deficiency. Although we found no evidence of overt hepatocellular damage during the course of the experiment, we observed significant alterations of cellular metabolism, especially in hepatocytes (i.e., histology, amino acid content, COX activity). Changes in serum parameters were detected, although their suitability as biomarkers will require additional research. The absence of hematocrit decrease is noteworthy in light of published literature; longer term investigations are necessary to further our understanding of taurine functions in teleosts. This manuscript presents results of scientific research relevant to the field of aquaculture. Taurine is a nutrient of great importance for many teleost species and for the sustainability of fish feeds; yet its metabolic functions remain unclear. This study constitutes, to the authors' knowledge, the first attempt at characterizing these functions. These results shed light on the complexities of taurine metabolism and emphasize possible hypotheses for future research. Therefore this study presents novel research results of high interest to the aquaculture and fish biology communities." @default.
• W1865227921 created "2016-06-24" @default.
• W1865227921 creator A5005681723 @default.
• W1865227921 creator A5060468901 @default.
• W1865227921 creator A5070124816 @default.
• W1865227921 creator A5074867606 @default.
• W1865227921 creator A5083805463 @default.
• W1865227921 date "2016-01-01" @default.
• W1865227921 modified "2023-10-17" @default.
• W1865227921 title "Investigation of biomarkers of early taurine deficiency in Florida pompano Trachinotus carolinus" @default.
• W1865227921 cites W1596776668 @default.
• W1865227921 cites W1966500253 @default.
• W1865227921 cites W1967082996 @default.
• W1865227921 cites W1969670678 @default.
• W1865227921 cites W1969785551 @default.
• W1865227921 cites W1969929352 @default.
• W1865227921 cites W1970332007 @default.
• W1865227921 cites W1971215515 @default.
• W1865227921 cites W1973855646 @default.
• W1865227921 cites W1975535702 @default.
• W1865227921 cites W1979244381 @default.
• W1865227921 cites W1989028007 @default.
• W1865227921 cites W1990591017 @default.
• W1865227921 cites W1992151788 @default.
• W1865227921 cites W1992513928 @default.
• W1865227921 cites W1992718584 @default.
• W1865227921 cites W1997572341 @default.
• W1865227921 cites W2000502745 @default.
• W1865227921 cites W2003209913 @default.
• W1865227921 cites W2004254908 @default.
• W1865227921 cites W2004851486 @default.
• W1865227921 cites W2005763905 @default.
• W1865227921 cites W2010543509 @default.
• W1865227921 cites W2012053263 @default.
• W1865227921 cites W2017376578 @default.
• W1865227921 cites W2019106819 @default.
• W1865227921 cites W2021902604 @default.
• W1865227921 cites W2025006105 @default.
• W1865227921 cites W2030530702 @default.
• W1865227921 cites W2034907863 @default.
• W1865227921 cites W2036080326 @default.
• W1865227921 cites W2043699264 @default.
• W1865227921 cites W2043936799 @default.
• W1865227921 cites W2044562220 @default.
• W1865227921 cites W2045724129 @default.
• W1865227921 cites W2050268779 @default.
• W1865227921 cites W2052876167 @default.
• W1865227921 cites W2056391909 @default.
• W1865227921 cites W2059958771 @default.
• W1865227921 cites W2061446144 @default.
• W1865227921 cites W2062191487 @default.
• W1865227921 cites W2065051086 @default.
• W1865227921 cites W2066539333 @default.
• W1865227921 cites W2066964768 @default.
• W1865227921 cites W2070194162 @default.
• W1865227921 cites W2070825055 @default.
• W1865227921 cites W2075619489 @default.
• W1865227921 cites W2078729859 @default.
• W1865227921 cites W2079323720 @default.
• W1865227921 cites W2079942099 @default.
• W1865227921 cites W2081840206 @default.
• W1865227921 cites W2084135247 @default.
• W1865227921 cites W2087444722 @default.
• W1865227921 cites W2091803996 @default.
• W1865227921 cites W2095584893 @default.
• W1865227921 cites W2099848669 @default.
• W1865227921 cites W2104603131 @default.
• W1865227921 cites W2105445758 @default.
• W1865227921 cites W2114062669 @default.
• W1865227921 cites W2115438056 @default.
• W1865227921 cites W2116401151 @default.
• W1865227921 cites W2132310053 @default.
• W1865227921 cites W2139723407 @default.
• W1865227921 cites W2140027980 @default.
• W1865227921 cites W2152129888 @default.
• W1865227921 cites W2161142660 @default.
• W1865227921 cites W2161222213 @default.
• W1865227921 cites W2168319145 @default.
• W1865227921 cites W2177909750 @default.
• W1865227921 cites W2334018613 @default.
• W1865227921 cites W4238707635 @default.
• W1865227921 cites W635923015 @default.
• W1865227921 cites W66623420 @default.
• W1865227921 doi "https://doi.org/10.1016/j.aquaculture.2015.09.019" @default.
• W1865227921 hasPublicationYear "2016" @default.
• W1865227921 type Work @default.
• W1865227921 sameAs 1865227921 @default.
• W1865227921 citedByCount "27" @default.
• W1865227921 countsByYear W18652279212015 @default.
• W1865227921 countsByYear W18652279212016 @default.
• W1865227921 countsByYear W18652279212017 @default.
• W1865227921 countsByYear W18652279212018 @default.
• W1865227921 countsByYear W18652279212019 @default.
• W1865227921 countsByYear W18652279212020 @default.
• W1865227921 countsByYear W18652279212021 @default.
• W1865227921 countsByYear W18652279212022 @default.
• W1865227921 crossrefType "journal-article" @default.
• W1865227921 hasAuthorship W1865227921A5005681723 @default.

• next