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- W186535260 abstract "With 39.5 million people worldwide living with human immunodeficiency virus (HIV) infection, acquired immune deficiency syndrome is one of the most destructive pandemics in recorded history. No vaccine or cure has been developed, so treatment of this disease relies on antiretroviral therapy. Currently, 22 antiretroviral drugs are available in four classes: a fusion inhibitor, nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), and protease inhibitors (PIs). Many more potential antiretroviral drugs in these classes are in preclinical and clinical development. Furthermore, new classes of antiretroviral drugs are being developed, including attachment and co-receptor inhibitors, integrase inhibitors, and maturation inhibitors. Patients are normally treated with a combination of three antiretroviral agents: two NRTIs along with one NNRTI or PI. This treatment paradigm, known as highly active antiretroviral therapy, can often reduce a patient's viral load to below detectable levels for prolonged periods. However, due to the rapid mutation of the virus, drug-resistant HIV strains are constantly evolving. The need for effective antiretroviral agents is now as strong as ever." @default.
- W186535260 created "2016-06-24" @default.
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- W186535260 date "2008-01-01" @default.
- W186535260 modified "2023-10-14" @default.
- W186535260 title "Human Immunodeficiency Viruses: Antiretroviral Agents" @default.
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- W186535260 doi "https://doi.org/10.1016/b978-012374410-4.00429-5" @default.
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