FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1865596247> ?p ?o ?g. }

• W1865596247 endingPage "2966" @default.
• W1865596247 startingPage "2957" @default.
• W1865596247 abstract "We explored the acute multifunctional effects of polyphenols from Hibiscus sabdariffa in humans to assess possible consequences on the host's health. The expected dynamic response was studied using a combination of transcriptomics and metabolomics to integrate specific functional pathways through network-based methods and to generate hypotheses established by acute metabolic effects and/or modifications in the expression of relevant genes. Data were obtained from healthy male volunteers after 3 hours of ingestion of an aqueous Hibiscus sabdariffa extract. The data were compared with data obtained prior to the ingestion, and the overall findings suggest that these particular polyphenols had a simultaneous role in mitochondrial function, energy homeostasis and protection of the cardiovascular system. These findings suggest beneficial actions in inflammation, endothelial dysfunction, and oxidation, which are interrelated mechanisms. Among other effects, the activation of the heme oxygenase-biliverdin reductase axis, the systemic inhibition of the renin-angiotensin system, the inhibition of the angiotensin-converting enzyme, and several actions mirroring those of the peroxisome proliferator-activated receptor agonists further support this notion. We also found concordant findings in the serum of the participants, which include a decrease in cortisol levels and a significant increase in the active vasodilator metabolite of bradykinin (des-Arg(9)-bradykinin). Therefore, our data support the view that polyphenols from Hibiscus sabdariffa play a regulatory role in metabolic health and in the maintenance of blood pressure, thus implying a multi-faceted impact in metabolic and cardiovascular diseases." @default.
• W1865596247 created "2016-06-24" @default.
• W1865596247 creator A5005699800 @default.
• W1865596247 creator A5005825666 @default.
• W1865596247 creator A5007407500 @default.
• W1865596247 creator A5037174678 @default.
• W1865596247 creator A5041769532 @default.
• W1865596247 creator A5053243054 @default.
• W1865596247 creator A5053780005 @default.
• W1865596247 creator A5073241369 @default.
• W1865596247 creator A5074855536 @default.
• W1865596247 creator A5077187730 @default.
• W1865596247 creator A5079206491 @default.
• W1865596247 date "2015-01-01" @default.
• W1865596247 modified "2023-10-08" @default.
• W1865596247 title "The acute impact of polyphenols from Hibiscus sabdariffa in metabolic homeostasis: an approach combining metabolomics and gene-expression analyses" @default.
• W1865596247 cites W1479919834 @default.
• W1865596247 cites W1504533062 @default.
• W1865596247 cites W1544419680 @default.
• W1865596247 cites W1777223861 @default.
• W1865596247 cites W1821762998 @default.
• W1865596247 cites W1897553699 @default.
• W1865596247 cites W1913030612 @default.
• W1865596247 cites W1941556871 @default.
• W1865596247 cites W1964853932 @default.
• W1865596247 cites W1969067234 @default.
• W1865596247 cites W1969898963 @default.
• W1865596247 cites W1970588407 @default.
• W1865596247 cites W1972306678 @default.
• W1865596247 cites W1973662041 @default.
• W1865596247 cites W1973944357 @default.
• W1865596247 cites W1977118644 @default.
• W1865596247 cites W1977810373 @default.
• W1865596247 cites W1978517521 @default.
• W1865596247 cites W1979189704 @default.
• W1865596247 cites W1980270094 @default.
• W1865596247 cites W1981343290 @default.
• W1865596247 cites W1985104380 @default.
• W1865596247 cites W1986666681 @default.
• W1865596247 cites W1989999208 @default.
• W1865596247 cites W1994938555 @default.
• W1865596247 cites W2000180786 @default.
• W1865596247 cites W2006690432 @default.
• W1865596247 cites W2011336591 @default.
• W1865596247 cites W2017987256 @default.
• W1865596247 cites W2018166539 @default.
• W1865596247 cites W2019711539 @default.
• W1865596247 cites W2021046573 @default.
• W1865596247 cites W2027050699 @default.
• W1865596247 cites W2030272662 @default.
• W1865596247 cites W2037927825 @default.
• W1865596247 cites W2039961296 @default.
• W1865596247 cites W2042438674 @default.
• W1865596247 cites W2046325531 @default.
• W1865596247 cites W2048213069 @default.
• W1865596247 cites W2054270918 @default.
• W1865596247 cites W2061942966 @default.
• W1865596247 cites W2062533676 @default.
• W1865596247 cites W2063414090 @default.
• W1865596247 cites W2068256216 @default.
• W1865596247 cites W2077893876 @default.
• W1865596247 cites W2079862480 @default.
• W1865596247 cites W207998093 @default.
• W1865596247 cites W2083428177 @default.
• W1865596247 cites W2100509778 @default.
• W1865596247 cites W2102523096 @default.
• W1865596247 cites W2104082616 @default.
• W1865596247 cites W2104858487 @default.
• W1865596247 cites W2104921361 @default.
• W1865596247 cites W2111577111 @default.
• W1865596247 cites W2121055396 @default.
• W1865596247 cites W2129403061 @default.
• W1865596247 cites W2131848047 @default.
• W1865596247 cites W2135642745 @default.
• W1865596247 cites W2135657957 @default.
• W1865596247 cites W2137543153 @default.
• W1865596247 cites W2139752415 @default.
• W1865596247 cites W2139987952 @default.
• W1865596247 cites W2140239055 @default.
• W1865596247 cites W2147798082 @default.
• W1865596247 cites W2148026781 @default.
• W1865596247 cites W2150926065 @default.
• W1865596247 cites W2153109972 @default.
• W1865596247 cites W2159686118 @default.
• W1865596247 cites W2160234571 @default.
• W1865596247 cites W2165918189 @default.
• W1865596247 cites W2167065750 @default.
• W1865596247 cites W2170989872 @default.
• W1865596247 cites W2227469764 @default.
• W1865596247 cites W2301545263 @default.
• W1865596247 cites W4294216483 @default.
• W1865596247 cites W986965488 @default.
• W1865596247 doi "https://doi.org/10.1039/c5fo00696a" @default.
• W1865596247 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26234931" @default.
• W1865596247 hasPublicationYear "2015" @default.
• W1865596247 type Work @default.
• W1865596247 sameAs 1865596247 @default.
• W1865596247 citedByCount "23" @default.

• next