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- W1865601972 abstract "There are two classes of nitrovasodilators used clinically: the organic nitrates (nitroglycerin, isosorbide dinitrate, and isosorbide-5-mononitrate) and the metal nitrosyls (sodium nitroprusside).Nitrovasodilators themselves are inactive and must release vasoactive nitric oxide (NO) or its related species to exert their pharmacological effects. The metabolic end-products of nitrovasodilators are nitrite and nitrate, and increased exposure to these ions can be significant especially when nitrovasodilators are used on a chronic basis.In addition to their effects on vasotone, nitrovasodilators are also potent anti-platelet agents.Nitrovasodilators are used for the management of several cardiovascular pathologies including stable and unstable angina, congestive heart failure, and myocardial infarction.Metabolism of organic nitrates can be categorized as mechanism-based (releasing NO) or clearance-based (releasing nitrite). Various enzymes, including mitochondrial aldehyde dehydrogenase and glutathione-S-transferase, play key roles in these processes.Tolerance to the vasodilatory effects of organic nitrates is mediated via oxidation of multiple protein cysteine groups, producing a myriad of downstream events. A nitrate-free period is used clinically to circumvent this loss of efficacy.Organic nitrates can induce endothelial dysfunction through increased oxidative stress and several studies have questioned the long-term safety of these agents.Cyanide radical release from the nitroprusside complex and its rapid elimination precludes the use of sodium nitroprusside on a chronic basis." @default.
- W1865601972 created "2016-06-24" @default.
- W1865601972 creator A5036932694 @default.
- W1865601972 creator A5043517883 @default.
- W1865601972 date "2011-01-01" @default.
- W1865601972 modified "2023-09-25" @default.
- W1865601972 title "Pharmacology of Nitrovasodilators" @default.
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