FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W186569618> ?p ?o ?g. }

• W186569618 endingPage "2894" @default.
• W186569618 startingPage "2889" @default.
• W186569618 abstract "OBJECTIVE To study the protective effects of ulinastatin (UTI), a human trypsin inhibitor, on the damage to the functions of multiple organs at the early stage of severe burn. METHODS (1) Twelve male mini-pigs, inflicted with III degrees burn with 35% total body surface area (TBSA), were randomly divided into two equal groups: Group A (control group, treated with fluid resuscitation immediately after injury and normal saline by intravenous drip tid) and Group B (UTI-treated group, in addition to fluid resuscitation UTI 5000 U/kg was given one hour after injury, 3 times/day). Blood samples were taken for the determination of serum TNF-alpha, IL-6, malonyldiadehyde (MDA), superoxide dismutase (SOD), alanine transaminase (ALT), aspartate transaminase (AST), creatine kinase (CK), MB isoenzyme of CK (CK-MB), blood urea nitrogen (BUN), creatinine (Cr), diamine oxidase (DAO), and D-lactate before and 6, 24, 48, and 72 hours after injury. (2) Forty hospitalized patients with 50%-70% TBSA partial and full thickness burn, 28 males and 12 females, aged 18-60, were randomly divided into routine treatment group (n = 16, receiving routine fluid resuscitation and wound management and normal saline IV drop bid for 7 days) and UTI treatment group (n = 24, in addition to the routine treatment UTI 400,000 U was given IV drop bid for 7 days). Sixteen healthy volunteers served as controls to undergo blood examination. The average body temperature (T), respiratory rate (R), systole blood pressure (BP) were detected 48 hours after burn. Blood samples were taken to determine the plasma lipopolysaccharide (LPS), and serum TNF-alpha, norepinephrine (NE), myeloperoxidase (MPO), ALT, AST, CK, CK-MB, lactic dehydrogenase (LDH), BUN, and Cr 1, 3, and 7 days after burn. RESULTS (1) The serum TNF-alpha, IL-6, and MDA levels significantly increased, and the serum SOD level significantly decreased 6 hours after burn in the mini-pings in both groups (all P < 0.05), and the changes in Group A were more significant than in Group B (all P < 0.05). The serum AST, CK, CK-MB, BUN, Cr, DAO, and D-lactate levels increased in the mini-pigs of both groups after severe burn in comparison with those before burn (all P < 0.05), especially in Group A in comparison with Group B (all P < 0.05). However, the serum levels of ALT and LDH of Group B did not increase significantly in comparison with those before burn. (2) The serum LPS, TNF-alpha, NE, ALT, AST, CK, CKMB, LDH, BUN, Cr, and MPO significantly increased after burn and began to decrease since the 7th day after burn, and the decrease levels in the UTI group were more significant than in the routine treatment group (all P < 0.05). In the routine treatment group 2 cases of sepsis were found and one case died of multiple organ failure; no complication was found in the UTI treatment group. CONCLUSION UTI can significantly lessen the production of inflammatory mediators and oxygen free radical and protect the functions of multiple organs after severe burn." @default.
• W186569618 created "2016-06-24" @default.
• W186569618 creator A5025167129 @default.
• W186569618 creator A5029638418 @default.
• W186569618 creator A5031261707 @default.
• W186569618 creator A5046354785 @default.
• W186569618 creator A5061501683 @default.
• W186569618 creator A5070959015 @default.
• W186569618 creator A5086108075 @default.
• W186569618 creator A5087920969 @default.
• W186569618 date "2005-11-02" @default.
• W186569618 modified "2023-10-05" @default.
• W186569618 title "Protective effects of ulinastatin against multiple organic damage after severe burn injury:experimental and clinic studies" @default.
• W186569618 doi "https://doi.org/10.3760/j:issn:0376-2491.2005.41.004" @default.
• W186569618 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16324360" @default.
• W186569618 hasPublicationYear "2005" @default.
• W186569618 type Work @default.
• W186569618 sameAs 186569618 @default.
• W186569618 citedByCount "2" @default.
• W186569618 countsByYear W1865696182017 @default.
• W186569618 crossrefType "journal-article" @default.
• W186569618 hasAuthorship W186569618A5025167129 @default.
• W186569618 hasAuthorship W186569618A5029638418 @default.
• W186569618 hasAuthorship W186569618A5031261707 @default.
• W186569618 hasAuthorship W186569618A5046354785 @default.
• W186569618 hasAuthorship W186569618A5061501683 @default.
• W186569618 hasAuthorship W186569618A5070959015 @default.
• W186569618 hasAuthorship W186569618A5086108075 @default.
• W186569618 hasAuthorship W186569618A5087920969 @default.
• W186569618 hasConcept C126322002 @default.
• W186569618 hasConcept C141071460 @default.
• W186569618 hasConcept C160160445 @default.
• W186569618 hasConcept C181199279 @default.
• W186569618 hasConcept C185592680 @default.
• W186569618 hasConcept C2776782833 @default.
• W186569618 hasConcept C2777397205 @default.
• W186569618 hasConcept C2778165595 @default.
• W186569618 hasConcept C2778176769 @default.
• W186569618 hasConcept C2778606649 @default.
• W186569618 hasConcept C2779053737 @default.
• W186569618 hasConcept C2779679107 @default.
• W186569618 hasConcept C2779896295 @default.
• W186569618 hasConcept C2780306776 @default.
• W186569618 hasConcept C2781246285 @default.
• W186569618 hasConcept C2993242423 @default.
• W186569618 hasConcept C36880943 @default.
• W186569618 hasConcept C42219234 @default.
• W186569618 hasConcept C55493867 @default.
• W186569618 hasConcept C71924100 @default.
• W186569618 hasConcept C90924648 @default.
• W186569618 hasConceptScore W186569618C126322002 @default.
• W186569618 hasConceptScore W186569618C141071460 @default.
• W186569618 hasConceptScore W186569618C160160445 @default.
• W186569618 hasConceptScore W186569618C181199279 @default.
• W186569618 hasConceptScore W186569618C185592680 @default.
• W186569618 hasConceptScore W186569618C2776782833 @default.
• W186569618 hasConceptScore W186569618C2777397205 @default.
• W186569618 hasConceptScore W186569618C2778165595 @default.
• W186569618 hasConceptScore W186569618C2778176769 @default.
• W186569618 hasConceptScore W186569618C2778606649 @default.
• W186569618 hasConceptScore W186569618C2779053737 @default.
• W186569618 hasConceptScore W186569618C2779679107 @default.
• W186569618 hasConceptScore W186569618C2779896295 @default.
• W186569618 hasConceptScore W186569618C2780306776 @default.
• W186569618 hasConceptScore W186569618C2781246285 @default.
• W186569618 hasConceptScore W186569618C2993242423 @default.
• W186569618 hasConceptScore W186569618C36880943 @default.
• W186569618 hasConceptScore W186569618C42219234 @default.
• W186569618 hasConceptScore W186569618C55493867 @default.
• W186569618 hasConceptScore W186569618C71924100 @default.
• W186569618 hasConceptScore W186569618C90924648 @default.
• W186569618 hasIssue "41" @default.
• W186569618 hasLocation W1865696181 @default.
• W186569618 hasLocation W1865696182 @default.
• W186569618 hasOpenAccess W186569618 @default.
• W186569618 hasPrimaryLocation W1865696181 @default.
• W186569618 hasRelatedWork W209340097 @default.
• W186569618 hasRelatedWork W2351576376 @default.
• W186569618 hasRelatedWork W2357007827 @default.
• W186569618 hasRelatedWork W2364323011 @default.
• W186569618 hasRelatedWork W2366672537 @default.
• W186569618 hasRelatedWork W2371991835 @default.
• W186569618 hasRelatedWork W2375532360 @default.
• W186569618 hasRelatedWork W2381762649 @default.
• W186569618 hasRelatedWork W2388815052 @default.
• W186569618 hasRelatedWork W2393589462 @default.
• W186569618 hasRelatedWork W2393909677 @default.
• W186569618 hasRelatedWork W2394471553 @default.
• W186569618 hasRelatedWork W2417385855 @default.
• W186569618 hasRelatedWork W2624339258 @default.
• W186569618 hasRelatedWork W3028893628 @default.
• W186569618 hasRelatedWork W3029337766 @default.
• W186569618 hasRelatedWork W3031864385 @default.
• W186569618 hasRelatedWork W3032130297 @default.
• W186569618 hasRelatedWork W3032434934 @default.
• W186569618 hasRelatedWork W3145953781 @default.
• W186569618 hasVolume "85" @default.
• W186569618 isParatext "false" @default.

• next