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- W1865875550 abstract "4042 Background: A phase I-II study of neo-adjuvant cisplatin, 5-FU, paclitaxel and radiation (PFT-R) performed at our institution yielded encouraging pathologic complete response (pCR) rates, but with significant toxicity. This retrospective study was designed to examine the results of our experience with PFT-R compared to our experience with cisplatin, 5-FU and RT (PF-R) in patients with locally advanced esophageal cancer. Methods: We searched the MGH cancer registry for all patients with esophageal cancer treated with radiation (RT) and chemotherapy between 1994–2002. Records of patients treated with curative, neo-adjuvant therapy were examined for chemotherapeutic regimen. The outcomes of patients treated with PF-R or PFT-R were assessed for response to therapy, toxicity, and survival. Most patients received two cycles of either cisplatin 25 mg/m2, 5-FU 1000 mg/m2 or cisplatin 20 mg/m2, 5-FU 800 mg/m2 and taxol 100 mg/m2 with a median RT dose of 54 Gy. Results: 177 patients were treated with a curativ..." @default.
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- W1865875550 date "2004-07-15" @default.
- W1865875550 modified "2023-09-26" @default.
- W1865875550 title "Neo-adjuvant radiation, cisplatin, 5-FU +/− paclitaxel in locally advanced esophageal cancer" @default.
- W1865875550 doi "https://doi.org/10.1200/jco.2004.22.90140.4042" @default.
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