Matches in SemOpenAlex for { <https://semopenalex.org/work/W186602103> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W186602103 abstract "The evaluation of chronic activity of the hypothalamic-pituitary-adrenal (HPA) axis is critical for determining the impact of chronic stressful situations. The potential use of hair glucocorticoids as a non-invasive, retrospective, biomarker of long term HPA activity is of great interest, and it is gaining acceptance in humans and animals. However, there are still no studies in literature examining hair cortisol concentration in pigs and corticosterone concentration in laboratory rodents. Therefore, we developed and validated, for the first time, a method for measuring hair glucocorticoids concentration in commercial sows and in Sprague-Dawley rats. Our preliminary data demonstrated: 1) a validated and specific washing protocol and extraction assay method with a good sensitivity in both species; 2) the effect of the reproductive phase, housing conditions and seasonality on hair cortisol concentration in sows; 3) similar hair corticosterone concentration in male and female rats; 4) elevated hair corticosterone concentration in response to chronic stress manipulations and chronic ACTH administration, demonstrating that hair provides a good direct index of HPA activity over long periods than other indirect parameters, such adrenal or thymus weight. From these results we believe that this new non-invasive tool needs to be applied to better characterize the overall impact in livestock animals and in laboratory rodents of chronic stressful situations that negatively affect animals welfare. Nevertheless, further studies are needed to improve this methodology and maybe to develop animal models for chronic stress of high interest and translational value in human medicine." @default.
- W186602103 created "2016-06-24" @default.
- W186602103 creator A5031500606 @default.
- W186602103 date "2014-06-11" @default.
- W186602103 modified "2023-09-24" @default.
- W186602103 title "Validation of a new method to assess the long-term Hypothalamic-Pituitary-Adrenal Activity using hair glucocorticoids as biomarkers. - Studies on pigs and laboratory Sprague-Dawley Rats" @default.
- W186602103 doi "https://doi.org/10.6092/unibo/amsdottorato/6276" @default.
- W186602103 hasPublicationYear "2014" @default.
- W186602103 type Work @default.
- W186602103 sameAs 186602103 @default.
- W186602103 citedByCount "0" @default.
- W186602103 crossrefType "dissertation" @default.
- W186602103 hasAuthorship W186602103A5031500606 @default.
- W186602103 hasConcept C126322002 @default.
- W186602103 hasConcept C134018914 @default.
- W186602103 hasConcept C2778654844 @default.
- W186602103 hasConcept C2779146795 @default.
- W186602103 hasConcept C2780352252 @default.
- W186602103 hasConcept C2781197716 @default.
- W186602103 hasConcept C42407357 @default.
- W186602103 hasConcept C55493867 @default.
- W186602103 hasConcept C71315377 @default.
- W186602103 hasConcept C71924100 @default.
- W186602103 hasConcept C86803240 @default.
- W186602103 hasConceptScore W186602103C126322002 @default.
- W186602103 hasConceptScore W186602103C134018914 @default.
- W186602103 hasConceptScore W186602103C2778654844 @default.
- W186602103 hasConceptScore W186602103C2779146795 @default.
- W186602103 hasConceptScore W186602103C2780352252 @default.
- W186602103 hasConceptScore W186602103C2781197716 @default.
- W186602103 hasConceptScore W186602103C42407357 @default.
- W186602103 hasConceptScore W186602103C55493867 @default.
- W186602103 hasConceptScore W186602103C71315377 @default.
- W186602103 hasConceptScore W186602103C71924100 @default.
- W186602103 hasConceptScore W186602103C86803240 @default.
- W186602103 hasLocation W1866021031 @default.
- W186602103 hasOpenAccess W186602103 @default.
- W186602103 hasPrimaryLocation W1866021031 @default.
- W186602103 hasRelatedWork W186352477 @default.
- W186602103 hasRelatedWork W1948770148 @default.
- W186602103 hasRelatedWork W1965916291 @default.
- W186602103 hasRelatedWork W1987550068 @default.
- W186602103 hasRelatedWork W2000010251 @default.
- W186602103 hasRelatedWork W2006578440 @default.
- W186602103 hasRelatedWork W2009262680 @default.
- W186602103 hasRelatedWork W2039356778 @default.
- W186602103 hasRelatedWork W2055242462 @default.
- W186602103 hasRelatedWork W2070243044 @default.
- W186602103 hasRelatedWork W2100602343 @default.
- W186602103 hasRelatedWork W2134711001 @default.
- W186602103 hasRelatedWork W2147002336 @default.
- W186602103 hasRelatedWork W2176945369 @default.
- W186602103 hasRelatedWork W2932158579 @default.
- W186602103 hasRelatedWork W2937741385 @default.
- W186602103 hasRelatedWork W2998654763 @default.
- W186602103 hasRelatedWork W3046274167 @default.
- W186602103 hasRelatedWork W3173683421 @default.
- W186602103 hasRelatedWork W3210306693 @default.
- W186602103 isParatext "false" @default.
- W186602103 isRetracted "false" @default.
- W186602103 magId "186602103" @default.
- W186602103 workType "dissertation" @default.