FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1866073711> ?p ?o ?g. }

• W1866073711 endingPage "753" @default.
• W1866073711 startingPage "745" @default.
• W1866073711 abstract "D10.G4.1 (D10) cells, a murine conalbumin-reactive Th2 cell line, made to overexpress the beta(2) integrin LFA-1 by pharmacological manipulation or by transfection become autoreactive and are capable of inducing in vivo autoimmunity. However, whether this is specific to LFA-1 and whether overexpression of other T cell integrin molecules has the same effect are unknown. We examined the functional consequences of T cell CD49d (alpha(4) integrin) overexpression by transfecting murine CD49d cDNA into D10 cells. Similar to the LFA-1-transfected cells, the CD49d-overexpressing T cells are autoreactive and proliferate in response to APCs in an MHC class II-dependent manner in the absence of nominal Ag. Additionally, CD49d overexpression is associated with increased in vitro adhesion to endothelial cells and increased in vivo splenic homing. However, in contrast to LFA-1 overexpression, increased T cell CD49d expression is not associated with autoreactive cytotoxicity or the ability to induce in vivo autoimmunity. In addition to the novel observation that CD49d overexpression is sufficient to induce T cell autoreactivity, our results also support the hypothesis that the ability to induce in vivo autoimmunity is related to T cell cytotoxicity and not to T cell proliferation function in the D10 murine adoptive transfer model of autoimmunity." @default.
• W1866073711 created "2016-06-24" @default.
• W1866073711 creator A5044313479 @default.
• W1866073711 creator A5044765695 @default.
• W1866073711 creator A5052110481 @default.
• W1866073711 creator A5056512744 @default.
• W1866073711 creator A5081607950 @default.
• W1866073711 creator A5082857859 @default.
• W1866073711 creator A5088877031 @default.
• W1866073711 creator A5091488480 @default.
• W1866073711 date "2003-07-15" @default.
• W1866073711 modified "2023-10-10" @default.
• W1866073711 title "CD49d Overexpression and T Cell Autoimmunity" @default.
• W1866073711 cites W1512041316 @default.
• W1866073711 cites W1514064771 @default.
• W1866073711 cites W1547417644 @default.
• W1866073711 cites W1576773659 @default.
• W1866073711 cites W1599912281 @default.
• W1866073711 cites W1631432577 @default.
• W1866073711 cites W1659517295 @default.
• W1866073711 cites W1820868233 @default.
• W1866073711 cites W1823692109 @default.
• W1866073711 cites W1899752912 @default.
• W1866073711 cites W1925706823 @default.
• W1866073711 cites W1956729481 @default.
• W1866073711 cites W1975199858 @default.
• W1866073711 cites W1980791390 @default.
• W1866073711 cites W1984051873 @default.
• W1866073711 cites W1987273695 @default.
• W1866073711 cites W1998631235 @default.
• W1866073711 cites W2002649342 @default.
• W1866073711 cites W2003794283 @default.
• W1866073711 cites W2003794901 @default.
• W1866073711 cites W2007994777 @default.
• W1866073711 cites W2012903967 @default.
• W1866073711 cites W2014912378 @default.
• W1866073711 cites W2019347038 @default.
• W1866073711 cites W2036855155 @default.
• W1866073711 cites W2037060648 @default.
• W1866073711 cites W2047518433 @default.
• W1866073711 cites W2050303117 @default.
• W1866073711 cites W2052854585 @default.
• W1866073711 cites W2071543625 @default.
• W1866073711 cites W2080390935 @default.
• W1866073711 cites W2091833662 @default.
• W1866073711 cites W2098976753 @default.
• W1866073711 cites W2099675490 @default.
• W1866073711 cites W2104410998 @default.
• W1866073711 cites W2111600696 @default.
• W1866073711 cites W2113168577 @default.
• W1866073711 cites W2116195930 @default.
• W1866073711 cites W2116562044 @default.
• W1866073711 cites W2119741323 @default.
• W1866073711 cites W2125650988 @default.
• W1866073711 cites W2135658911 @default.
• W1866073711 cites W2135712089 @default.
• W1866073711 cites W2145082129 @default.
• W1866073711 cites W2152246919 @default.
• W1866073711 cites W2168456427 @default.
• W1866073711 cites W265645457 @default.
• W1866073711 doi "https://doi.org/10.4049/jimmunol.171.2.745" @default.
• W1866073711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12847241" @default.
• W1866073711 hasPublicationYear "2003" @default.
• W1866073711 type Work @default.
• W1866073711 sameAs 1866073711 @default.
• W1866073711 citedByCount "12" @default.
• W1866073711 countsByYear W18660737112014 @default.
• W1866073711 countsByYear W18660737112018 @default.
• W1866073711 countsByYear W18660737112021 @default.
• W1866073711 countsByYear W18660737112023 @default.
• W1866073711 crossrefType "journal-article" @default.
• W1866073711 hasAuthorship W1866073711A5044313479 @default.
• W1866073711 hasAuthorship W1866073711A5044765695 @default.
• W1866073711 hasAuthorship W1866073711A5052110481 @default.
• W1866073711 hasAuthorship W1866073711A5056512744 @default.
• W1866073711 hasAuthorship W1866073711A5081607950 @default.
• W1866073711 hasAuthorship W1866073711A5082857859 @default.
• W1866073711 hasAuthorship W1866073711A5088877031 @default.
• W1866073711 hasAuthorship W1866073711A5091488480 @default.
• W1866073711 hasBestOaLocation W18660737111 @default.
• W1866073711 hasConcept C1491633281 @default.
• W1866073711 hasConcept C151872237 @default.
• W1866073711 hasConcept C18903297 @default.
• W1866073711 hasConcept C195687474 @default.
• W1866073711 hasConcept C203014093 @default.
• W1866073711 hasConcept C2776090121 @default.
• W1866073711 hasConcept C2780130043 @default.
• W1866073711 hasConcept C54009773 @default.
• W1866073711 hasConcept C54355233 @default.
• W1866073711 hasConcept C55493867 @default.
• W1866073711 hasConcept C81885089 @default.
• W1866073711 hasConcept C86803240 @default.
• W1866073711 hasConcept C8891405 @default.
• W1866073711 hasConcept C90375314 @default.
• W1866073711 hasConcept C95444343 @default.
• W1866073711 hasConceptScore W1866073711C1491633281 @default.
• W1866073711 hasConceptScore W1866073711C151872237 @default.
• W1866073711 hasConceptScore W1866073711C18903297 @default.

• next