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• W1866091572 abstract "Analysis of micro RNA (mi RNA ) expression signatures in prostate cancer ( PC a) and castration‐resistant PC a has revealed that mi RNA ‐223 is significantly downregulated in cancer tissues, suggesting that miR‐223 acts as a tumor‐suppressive mi RNA by targeting oncogenes. The aim of this study was to investigate the functional roles of miR‐223 and identify downstream oncogenic targets regulated by miR‐223 in PC a cells. Functional studies of miR‐223 were carried out to investigate cell proliferation, migration, and invasion using PC 3 and PC 3M PC a cell lines. Restoration of miR‐223 significantly inhibited cancer cell migration and invasion in PC a cells. In silico database and genome‐wide gene expression analyses revealed that ITGA 3 and ITGB 1 were direct targets of miR‐223 regulation. Knockdown of ITGA 3 and ITGB 1 significantly inhibited cancer cell migration and invasion in PC a cells by regulating downstream signaling. Moreover, overexpression of ITGA 3 and ITGB 1 was observed in PC a clinical specimens. Thus, our data indicated that downregulation of miR‐223 enhanced ITGA 3/ ITGB 1 signaling and contributed to cancer cell migration and invasion in PC a cells. Elucidation of the molecular pathways modulated by tumor‐suppressive mi RNA s provides insights into the mechanisms of PC a progression and metastasis." @default.
• W1866091572 created "2016-06-24" @default.
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• W1866091572 date "2015-12-05" @default.
• W1866091572 modified "2023-10-18" @default.
• W1866091572 title "Tumor‐suppressive <i> micro <scp>RNA</scp> ‐223 </i> inhibits cancer cell migration and invasion by targeting <i> <scp>ITGA</scp> 3/ <scp>ITGB</scp> 1 </i> signaling in prostate cancer" @default.
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• W1866091572 doi "https://doi.org/10.1111/cas.12842" @default.
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• W1866091572 hasPublicationYear "2015" @default.
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