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• W1866253623 startingPage "430" @default.
• W1866253623 abstract "Vitronectin inhibits the membrane attack complex of the complement system and is found both in plasma and the extracellular matrix. In this study, we have identified the outer membrane protein Haemophilus surface fibrils (Hsf) as the major vitronectin-binding protein in encapsulated H. influenzae type b. A H. influenzae mutant devoid of Hsf showed a significantly decreased binding to both soluble and immobilized vitronectin as compared with the wild-type counterpart. Moreover, Escherichia coli-expressing Hsf at the surface strongly adhered to immobilized vitronectin. Importantly, the H. influenzae Hsf mutant had a markedly reduced survival as compared with the wild-type bacterium when incubated with normal human serum. A series of truncated Hsf fragments were recombinantly manufactured in E. coli. The vitronectin binding regions were located within two separate binding domains. In conclusion, Hsf interacts with vitronectin and thereby inhibits the complement-mediated bactericidal activity, and thus is a major H. influenzae virulence factor." @default.
• W1866253623 created "2016-06-24" @default.
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• W1866253623 creator A5054968150 @default.
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• W1866253623 date "2006-07-01" @default.
• W1866253623 modified "2023-10-16" @default.
• W1866253623 title "<i>Haemophilus influenzae</i> Surface Fibrils Contribute to Serum Resistance by Interacting with Vitronectin" @default.
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• W1866253623 doi "https://doi.org/10.4049/jimmunol.177.1.430" @default.
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• W1866253623 hasPublicationYear "2006" @default.
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