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• W1866639252 endingPage "7698" @default.
• W1866639252 startingPage "7688" @default.
• W1866639252 abstract "Poxviruses are unique among viruses in encoding members of the serine proteinase inhibitor (serpin) superfamily. Orthopoxviruses contain three serpins, designated SPI-1, SPI-2, and SPI-3. SPI-1 encodes a 40-kDa protein that is required for the replication of rabbitpox virus (RPV) in PK-15 or A549 cells in culture (A. N. Ali, P. C. Turner, M. A. Brooks, and R. W. Moyer, Virology 202:305-314, 1994). Examination of nonpermissive human A549 cells infected with an RPV mutant disrupted in the SPI-1 gene (RPV delta SPI-1) suggests there are no gross defects in protein or DNA synthesis. The proteolytic processing of late viral structural proteins, a feature of orthopoxvirus infections associated with the maturation of virus particles, also appears relatively normal. However, very few mature virus particles of any kind are produced compared with the level found in infections with wild-type RPV. Morphological examination of RPV delta SPI-1-infected A549 cells, together with an observed fragmentation of cellular DNA, suggests that the host range defect is associated with the onset of apoptosis. Apoptosis is seen only in RPV delta SPI-1 infection of nonpermissive (A549 or PK-15) cells and is absent in all wild-type RPV infections and RPV delta SPI-2 mutant infections examined to date. Although the SPI-1 gene is expressed early, before DNA replication, the triggering apoptotic event occurs late in the infection, as RPV delta SPI-1-infected A549 cells do not undergo apoptosis when infections are carried out in the presence of cytosine arabinoside. While the SPI-2 (crmA) gene, when transfected into cells, has been shown to inhibit apoptosis, our experiments provide the first indication that a poxvirus serpin protein can inhibit apoptosis during a poxvirus infection." @default.
• W1866639252 created "2016-06-24" @default.
• W1866639252 creator A5031406677 @default.
• W1866639252 creator A5034119895 @default.
• W1866639252 creator A5035169984 @default.
• W1866639252 creator A5069258780 @default.
• W1866639252 date "1995-12-01" @default.
• W1866639252 modified "2023-10-13" @default.
• W1866639252 title "A rabbitpox virus serpin gene controls host range by inhibiting apoptosis in restrictive cells" @default.
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• W1866639252 doi "https://doi.org/10.1128/jvi.69.12.7688-7698.1995" @default.
• W1866639252 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/189710" @default.
• W1866639252 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7494278" @default.
• W1866639252 hasPublicationYear "1995" @default.
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