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- W1866659834 endingPage "141" @default.
- W1866659834 startingPage "129" @default.
- W1866659834 abstract "MicroRNAs (miRNA/miR) play an important role in gene regulatory networks through targeting mRNAs. They are involved in diverse biological processes such as cell proliferation, differentiation, angiogenesis, and apoptosis. Due to their pivotal effects on multiple genes and pathways, dysregulated miRNAs have been reported to be associated with different diseases, including colorectal cancer (CRC). Recent evidence indicates that aberrant miRNA expression is tightly linked with the initiation and progression of CRC. To elucidate the influence of miRNA regulation in CRC, it is critical to identify dysregulated miRNAs, their target mRNA genes and their involvement in gene regulatory and signaling networks. Various experimental and computational studies have been conducted to decipher the function of miRNAs involved in CRC. Experimental studies that are used for this purpose can be classified into two categories: direct/individual and indirect/high-throughput gene expression studies. Here we review miRNA target identification studies related to CRC with an emphasis on experimental data based on Luciferase reporter assays. Recent advances in determining the function of miRNAs and the signaling pathways they are involved in have also been summarized. The review helps bioinformaticians and biologists to find extensive information about downstream targets of dysregulated miRNAs, and their pro-/anti-CRC effects." @default.
- W1866659834 created "2016-06-24" @default.
- W1866659834 creator A5022724143 @default.
- W1866659834 creator A5025055846 @default.
- W1866659834 creator A5079964077 @default.
- W1866659834 creator A5080211483 @default.
- W1866659834 creator A5083076919 @default.
- W1866659834 date "2015-01-23" @default.
- W1866659834 modified "2023-10-05" @default.
- W1866659834 title "MicroRNA-mRNA interactions in colorectal cancer and their role in tumor progression" @default.
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