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• W1866817321 abstract "The synthetic aminoacridine derivative amsacrine (m-AMSA) is capable of preventing DNA from serving as a template in replication and DNA synthesis. This mechanism of action is similar to that of anthracyclines, but clinical evidence suggests the lack of cross-resistance. The recommended dosage in patients with solid tumors is 90–120 mg/m2 intravenously every 3–4 weeks. Despite the initial encouraging reports from experimental models, m-AMSA has shown no real impact in the treatment of patients with a wide variety of solid tumors. In relapsed acute nonlymphocytic leukemia, 20–30% of patients will achieve complete remission. An increased remission rate is obtained when m-AMSA is combined with other agents, especially with high-dose cytosine arabinoside, with a complete remission rate of 50–60% in relapsed patients. Currently, several phase III trials are evaluating m-AMSA combinations against daunorubicin-containing regimens in patients with previously untreated acute leukemia. The potential role of these regimens in this disease remains to be defined." @default.
• W1866817321 created "2016-06-24" @default.
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• W1866817321 creator A5079997895 @default.
• W1866817321 date "1985-03-04" @default.
• W1866817321 modified "2023-09-27" @default.
• W1866817321 title "Amsacrine (m-AMSA): A New Antineoplastic Agent Pharmacology, Clinical Activity and Toxicity" @default.
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• W1866817321 doi "https://doi.org/10.1002/j.1875-9114.1985.tb03406.x" @default.
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