Matches in SemOpenAlex for { <https://semopenalex.org/work/W1866867488> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1866867488 endingPage "1000" @default.
- W1866867488 startingPage "996" @default.
- W1866867488 abstract "The present study was undertaken to determine whether or not spironolactone could induce drug-metabolizing enzymes in patients with ascites due to alcoholic cirrhosis of the liver. The disposition of antipyrine was therefore studied in 15 patients with cirrhosis before and after 13 days of spironolactone treatment (200 mg/day) and in 15 comparable patients not treated by spironolactone. In spironolactone-treated patients, a 40% increase in elimination rate constant of antipyrine (P less than 0.01) was due both to a decrease in apparent volume of distribution by 11% (P less than 0.01) and to a 20% rise in metabolic clearance rate (P less than 0.01). In control patients treated with furosemide or by paracentesis no significant change in metabolic clearance rate of antipyrine was found. As with spironolactone, furosemide decreased the apparent volume of distribution (9%, P less than 0.05) in proportion to the loss in body weight. Since spironolactone treatment was not associated with improvement in the fractional clearance of bromosulfophthalein, nor in serum albumin, prothrombin time, and factor V, the data are compatible with the idea that even in cirrhosis the hepatic drug-oxidizing enzymes were induced by spironolactone. Thus, the consequences of enzyme induction should be considered when spironolactone is associated with other drugs for the treatment of cirrhotic patients." @default.
- W1866867488 created "2016-06-24" @default.
- W1866867488 creator A5016703858 @default.
- W1866867488 creator A5017832857 @default.
- W1866867488 creator A5057427917 @default.
- W1866867488 creator A5073453228 @default.
- W1866867488 creator A5084045144 @default.
- W1866867488 date "1980-05-01" @default.
- W1866867488 modified "2023-10-14" @default.
- W1866867488 title "Spironolactone and enzyme induction in patients with alcoholic cirrhosis" @default.
- W1866867488 cites W1492383398 @default.
- W1866867488 cites W1519637961 @default.
- W1866867488 cites W1775964807 @default.
- W1866867488 cites W1911099575 @default.
- W1866867488 cites W1965877169 @default.
- W1866867488 cites W1966378417 @default.
- W1866867488 cites W1980515163 @default.
- W1866867488 cites W1996993597 @default.
- W1866867488 cites W2002664886 @default.
- W1866867488 cites W2005473203 @default.
- W1866867488 cites W2025793933 @default.
- W1866867488 cites W2025803857 @default.
- W1866867488 cites W2032892183 @default.
- W1866867488 cites W2069846822 @default.
- W1866867488 cites W2071399053 @default.
- W1866867488 cites W2078205693 @default.
- W1866867488 cites W2080213001 @default.
- W1866867488 cites W2085887263 @default.
- W1866867488 cites W2090227090 @default.
- W1866867488 cites W2093412446 @default.
- W1866867488 cites W2131314440 @default.
- W1866867488 cites W2154715249 @default.
- W1866867488 cites W2226961199 @default.
- W1866867488 cites W2256836828 @default.
- W1866867488 cites W2404794512 @default.
- W1866867488 cites W2408864191 @default.
- W1866867488 cites W2409912014 @default.
- W1866867488 cites W2413242803 @default.
- W1866867488 cites W2414655317 @default.
- W1866867488 cites W2472486924 @default.
- W1866867488 cites W6034197 @default.
- W1866867488 cites W74649421 @default.
- W1866867488 doi "https://doi.org/10.1016/0016-5085(80)90782-9" @default.
- W1866867488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7380205" @default.
- W1866867488 hasPublicationYear "1980" @default.
- W1866867488 type Work @default.
- W1866867488 sameAs 1866867488 @default.
- W1866867488 citedByCount "26" @default.
- W1866867488 countsByYear W18668674882016 @default.
- W1866867488 crossrefType "journal-article" @default.
- W1866867488 hasAuthorship W1866867488A5016703858 @default.
- W1866867488 hasAuthorship W1866867488A5017832857 @default.
- W1866867488 hasAuthorship W1866867488A5057427917 @default.
- W1866867488 hasAuthorship W1866867488A5073453228 @default.
- W1866867488 hasAuthorship W1866867488A5084045144 @default.
- W1866867488 hasBestOaLocation W18668674881 @default.
- W1866867488 hasConcept C112705442 @default.
- W1866867488 hasConcept C126322002 @default.
- W1866867488 hasConcept C134018914 @default.
- W1866867488 hasConcept C139254425 @default.
- W1866867488 hasConcept C2776379505 @default.
- W1866867488 hasConcept C2777214474 @default.
- W1866867488 hasConcept C2777955127 @default.
- W1866867488 hasConcept C2778525890 @default.
- W1866867488 hasConcept C2780496750 @default.
- W1866867488 hasConcept C71924100 @default.
- W1866867488 hasConceptScore W1866867488C112705442 @default.
- W1866867488 hasConceptScore W1866867488C126322002 @default.
- W1866867488 hasConceptScore W1866867488C134018914 @default.
- W1866867488 hasConceptScore W1866867488C139254425 @default.
- W1866867488 hasConceptScore W1866867488C2776379505 @default.
- W1866867488 hasConceptScore W1866867488C2777214474 @default.
- W1866867488 hasConceptScore W1866867488C2777955127 @default.
- W1866867488 hasConceptScore W1866867488C2778525890 @default.
- W1866867488 hasConceptScore W1866867488C2780496750 @default.
- W1866867488 hasConceptScore W1866867488C71924100 @default.
- W1866867488 hasIssue "5" @default.
- W1866867488 hasLocation W18668674881 @default.
- W1866867488 hasLocation W18668674882 @default.
- W1866867488 hasOpenAccess W1866867488 @default.
- W1866867488 hasPrimaryLocation W18668674881 @default.
- W1866867488 hasRelatedWork W1873458064 @default.
- W1866867488 hasRelatedWork W1971595373 @default.
- W1866867488 hasRelatedWork W1980583333 @default.
- W1866867488 hasRelatedWork W1987296894 @default.
- W1866867488 hasRelatedWork W1995192322 @default.
- W1866867488 hasRelatedWork W2084069177 @default.
- W1866867488 hasRelatedWork W2241027605 @default.
- W1866867488 hasRelatedWork W2312942238 @default.
- W1866867488 hasRelatedWork W2505326640 @default.
- W1866867488 hasRelatedWork W2589899659 @default.
- W1866867488 hasVolume "78" @default.
- W1866867488 isParatext "false" @default.
- W1866867488 isRetracted "false" @default.
- W1866867488 magId "1866867488" @default.
- W1866867488 workType "article" @default.