FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1867188112> ?p ?o ?g. }

• W1867188112 endingPage "87" @default.
• W1867188112 startingPage "77" @default.
• W1867188112 abstract "Objectives HIV ‐1 transmitted drug resistance ( TDR ) in treatment‐naïve individuals is a well‐described phenomenon. Baseline genotypic resistance testing is considered standard of care in most developed areas of the world. The aim of this analysis was to characterize HIV‐1 TDR and the use of resistance testing in START trial participants. Methods In the S trategic T iming of A nti R etroviral T reatment ( START ) trial, baseline genotypic resistance testing results were collected at study entry and analysed centrally to determine the prevalence of TDR in the study population. Resistance was based on a modified 2009 W orld H ealth O rganization definition to reflect newer resistance mutations. Results Baseline resistance testing was available in 1946 study participants. Higher rates of testing occurred in E urope (86.7%), the USA (81.3%) and A ustralia (89.9%) as compared with A sia (22.2%), S outh A merica (1.8%) and A frica (0.1%). The overall prevalence of TDR was 10.1%, more commonly to nonnucleoside reverse transcriptase inhibitors (4.5%) and nucleoside reverse transcriptase inhibitors (4%) compared with protease inhibitors (2.8%). The most frequent TDR mutations observed were M 41L, D 67 N / G / E , T 215 F / Y / I / S / C / D / E / V / N , 219 Q / E / N / R , K 103 N / S , and G 190 A / S / E in reverse transcriptase, and M 46 I /L and L 90 M in protease. By country, the prevalence of TDR was highest in A ustralia (17.5%), F rance (16.7%), the USA (12.6%) and S pain (12.6%). No participant characteristics were identified as predictors of the presence of TDR . Conclusions START participants enrolled in resource‐rich areas of the world were more likely to have baseline resistance testing. In E urope, the USA and A ustralia, TDR prevalence rates varied by country." @default.
• W1867188112 created "2016-06-24" @default.
• W1867188112 creator A5005370241 @default.
• W1867188112 creator A5006365972 @default.
• W1867188112 creator A5009094454 @default.
• W1867188112 creator A5033497327 @default.
• W1867188112 creator A5054324011 @default.
• W1867188112 creator A5054594687 @default.
• W1867188112 creator A5071708504 @default.
• W1867188112 creator A5081265552 @default.
• W1867188112 creator A5085619123 @default.
• W1867188112 creator A5088502098 @default.
• W1867188112 date "2015-02-25" @default.
• W1867188112 modified "2023-10-10" @default.
• W1867188112 title "Global HIV-1 transmitted drug resistance in the INSIGHT Strategic Timing of AntiRetroviral Treatment (START) trial" @default.
• W1867188112 cites W1516499810 @default.
• W1867188112 cites W1571027354 @default.
• W1867188112 cites W1726619610 @default.
• W1867188112 cites W1966063036 @default.
• W1867188112 cites W1974449256 @default.
• W1867188112 cites W2021978223 @default.
• W1867188112 cites W2024585092 @default.
• W1867188112 cites W2029531333 @default.
• W1867188112 cites W2032847961 @default.
• W1867188112 cites W2035095394 @default.
• W1867188112 cites W2037637997 @default.
• W1867188112 cites W2054469024 @default.
• W1867188112 cites W2067293915 @default.
• W1867188112 cites W2084686975 @default.
• W1867188112 cites W2086783015 @default.
• W1867188112 cites W2091110992 @default.
• W1867188112 cites W2091662160 @default.
• W1867188112 cites W2109046728 @default.
• W1867188112 cites W2117128648 @default.
• W1867188112 cites W2122858451 @default.
• W1867188112 cites W2123983643 @default.
• W1867188112 cites W2130131484 @default.
• W1867188112 cites W2131052560 @default.
• W1867188112 cites W2139311359 @default.
• W1867188112 cites W2141581406 @default.
• W1867188112 cites W2144882072 @default.
• W1867188112 cites W2145107025 @default.
• W1867188112 cites W2146906064 @default.
• W1867188112 cites W2147933179 @default.
• W1867188112 cites W2148750104 @default.
• W1867188112 cites W2149330759 @default.
• W1867188112 cites W2151983644 @default.
• W1867188112 cites W2154164013 @default.
• W1867188112 cites W2159226281 @default.
• W1867188112 cites W2163319656 @default.
• W1867188112 cites W2408763107 @default.
• W1867188112 cites W2438030319 @default.
• W1867188112 cites W3143197109 @default.
• W1867188112 cites W80380938 @default.
• W1867188112 doi "https://doi.org/10.1111/hiv.12236" @default.
• W1867188112 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4341921" @default.
• W1867188112 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25711326" @default.
• W1867188112 hasPublicationYear "2015" @default.
• W1867188112 type Work @default.
• W1867188112 sameAs 1867188112 @default.
• W1867188112 citedByCount "56" @default.
• W1867188112 countsByYear W18671881122015 @default.
• W1867188112 countsByYear W18671881122016 @default.
• W1867188112 countsByYear W18671881122017 @default.
• W1867188112 countsByYear W18671881122018 @default.
• W1867188112 countsByYear W18671881122019 @default.
• W1867188112 countsByYear W18671881122020 @default.
• W1867188112 countsByYear W18671881122021 @default.
• W1867188112 countsByYear W18671881122022 @default.
• W1867188112 countsByYear W18671881122023 @default.
• W1867188112 crossrefType "journal-article" @default.
• W1867188112 hasAuthorship W1867188112A5005370241 @default.
• W1867188112 hasAuthorship W1867188112A5006365972 @default.
• W1867188112 hasAuthorship W1867188112A5009094454 @default.
• W1867188112 hasAuthorship W1867188112A5033497327 @default.
• W1867188112 hasAuthorship W1867188112A5054324011 @default.
• W1867188112 hasAuthorship W1867188112A5054594687 @default.
• W1867188112 hasAuthorship W1867188112A5071708504 @default.
• W1867188112 hasAuthorship W1867188112A5081265552 @default.
• W1867188112 hasAuthorship W1867188112A5085619123 @default.
• W1867188112 hasAuthorship W1867188112A5088502098 @default.
• W1867188112 hasBestOaLocation W18671881121 @default.
• W1867188112 hasConcept C104317684 @default.
• W1867188112 hasConcept C114851261 @default.
• W1867188112 hasConcept C126322002 @default.
• W1867188112 hasConcept C135763542 @default.
• W1867188112 hasConcept C142462285 @default.
• W1867188112 hasConcept C156719811 @default.
• W1867188112 hasConcept C159047783 @default.
• W1867188112 hasConcept C2778451633 @default.
• W1867188112 hasConcept C2908647359 @default.
• W1867188112 hasConcept C2993143319 @default.
• W1867188112 hasConcept C3013748606 @default.
• W1867188112 hasConcept C49105822 @default.
• W1867188112 hasConcept C54355233 @default.
• W1867188112 hasConcept C71924100 @default.
• W1867188112 hasConcept C86803240 @default.
• W1867188112 hasConcept C99454951 @default.

• next