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• W1867241955 endingPage "5127" @default.
• W1867241955 startingPage "5121" @default.
• W1867241955 abstract "Eukaryotic organisms contain a multiprotein complex that includes Rpd3 histone deacetylase and the Sin3 corepressor. The Sin3-Rpd3 complex is recruited to promoters by specific DNA-binding proteins, whereupon it represses transcription. By directly analyzing the chromatin structure of a repressed promoter in yeast cells, we demonstrate that transcriptional repression is associated with localized histone deacetylation. Specifically, we observe decreased acetylation of histones H3 and H4 (preferentially lysines 5 and 12) that depends on the DNA-binding repressor (Ume6), Sin3, and Rpd3. Mapping experiments indicate that the domain of histone deacetylation is highly localized, occurring over a range of one to two nucleosomes. Taken together with previous observations, these results define a novel mechanism of transcriptional repression which involves targeted recruitment of a histone-modifying activity and localized perturbation of chromatin structure." @default.
• W1867241955 created "2016-06-24" @default.
• W1867241955 creator A5038869106 @default.
• W1867241955 creator A5083029357 @default.
• W1867241955 date "1998-09-01" @default.
• W1867241955 modified "2023-10-11" @default.
• W1867241955 title "Targeted Recruitment of the Sin3-Rpd3 Histone Deacetylase Complex Generates a Highly Localized Domain of Repressed Chromatin In Vivo" @default.
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• W1867241955 doi "https://doi.org/10.1128/mcb.18.9.5121" @default.
• W1867241955 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/109097" @default.
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• W1867241955 hasPublicationYear "1998" @default.
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