FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1867366263> ?p ?o ?g. }

• W1867366263 endingPage "614" @default.
• W1867366263 startingPage "611" @default.
• W1867366263 abstract "The advantages of using 113mIn particles for perfusion lung scanning have been documented by Stern et al. (1) and Wagner et al. (2). Published methods of preparing these particles use iron added as ferric chloride as a carrier. In our laboratory we used Gemill's method of preparing 113mIn macroaggregates but noted flushing and apprehension in some patients upon injection. Since this reaction was seen only when iron was added as a carrier to indium pharmaceuticals, we began to search for a more suitable carrier. Criteria used to assess the acceptability of a new carrier were that it should be less toxic than iron, the method of preparation should be at least as simple as that described by Gemill et al. (3), and the resulting scans should be of comparable quality to those obtained with iron particles. We have found that aluminum meets these criteria. Aluminum was first considered as a possible substitute for iron on the basis of its chemical properties. Both indium and aluminum are in Group 3 a of the periodic table and, therefore, should have similar chemical properties. Their titration curves as shown in Figure 1 are essentially identical. On the other hand, titration with NaOH results in complete formation of ferric hydroxide before indium and aluminum hydroxides have begun to form to any appreciable extent. Technics for the preparation of Fe(In)(OH)8 particles, therefore, require additional steps such as heating (3) or a double titration (1) in order for aggregates to form. With aluminum as the carrier, the hydroxides are formed simultaneously and, consequently, aggregated particles are formed by a single titration. Heating is required, however, to form the larger particles necessary for lung scanning because aluminum hydroxide and presumably indium hydroxide have the unique characteristic of decreasing in solubility as the temperature increases. Aluminum hydroxide is as insoluble as ferric hydroxide having a solubility constant of less than 10-30. Aluminum also has the advantage over iron of a single oxidation state of +3. This makes it possible to prepare aluminum stock solutions well in advance without fear of autoreduction. The method we have developed for the preparation of Al(113mIn)(OH)3 optimizes the parameters involved so that the resulting procedure is simple, reproducible, and requires minimum technician time." @default.
• W1867366263 created "2016-06-24" @default.
• W1867366263 creator A5007142750 @default.
• W1867366263 creator A5023993958 @default.
• W1867366263 creator A5044500012 @default.
• W1867366263 creator A5058310751 @default.
• W1867366263 creator A5068575989 @default.
• W1867366263 date "1969-09-01" @default.
• W1867366263 modified "2023-09-27" @default.
• W1867366263 title "113mIn (Aluminum) Hydroxide Particles for Lung Scanning" @default.
• W1867366263 doi "https://doi.org/10.1148/93.3.611" @default.
• W1867366263 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/5822737" @default.
• W1867366263 hasPublicationYear "1969" @default.
• W1867366263 type Work @default.
• W1867366263 sameAs 1867366263 @default.
• W1867366263 citedByCount "5" @default.
• W1867366263 crossrefType "journal-article" @default.
• W1867366263 hasAuthorship W1867366263A5007142750 @default.
• W1867366263 hasAuthorship W1867366263A5023993958 @default.
• W1867366263 hasAuthorship W1867366263A5044500012 @default.
• W1867366263 hasAuthorship W1867366263A5058310751 @default.
• W1867366263 hasAuthorship W1867366263A5068575989 @default.
• W1867366263 hasConcept C179104552 @default.
• W1867366263 hasConcept C184866935 @default.
• W1867366263 hasConcept C185592680 @default.
• W1867366263 hasConcept C191897082 @default.
• W1867366263 hasConcept C192562407 @default.
• W1867366263 hasConcept C2775896084 @default.
• W1867366263 hasConcept C2780534640 @default.
• W1867366263 hasConcept C513153333 @default.
• W1867366263 hasConcept C543292547 @default.
• W1867366263 hasConcept C71924100 @default.
• W1867366263 hasConceptScore W1867366263C179104552 @default.
• W1867366263 hasConceptScore W1867366263C184866935 @default.
• W1867366263 hasConceptScore W1867366263C185592680 @default.
• W1867366263 hasConceptScore W1867366263C191897082 @default.
• W1867366263 hasConceptScore W1867366263C192562407 @default.
• W1867366263 hasConceptScore W1867366263C2775896084 @default.
• W1867366263 hasConceptScore W1867366263C2780534640 @default.
• W1867366263 hasConceptScore W1867366263C513153333 @default.
• W1867366263 hasConceptScore W1867366263C543292547 @default.
• W1867366263 hasConceptScore W1867366263C71924100 @default.
• W1867366263 hasIssue "3" @default.
• W1867366263 hasLocation W18673662631 @default.
• W1867366263 hasLocation W18673662632 @default.
• W1867366263 hasOpenAccess W1867366263 @default.
• W1867366263 hasPrimaryLocation W18673662631 @default.
• W1867366263 hasRelatedWork W1977785243 @default.
• W1867366263 hasRelatedWork W1977811759 @default.
• W1867366263 hasRelatedWork W1992546636 @default.
• W1867366263 hasRelatedWork W1994138809 @default.
• W1867366263 hasRelatedWork W2061317193 @default.
• W1867366263 hasRelatedWork W2117317611 @default.
• W1867366263 hasRelatedWork W2313856548 @default.
• W1867366263 hasRelatedWork W2365007400 @default.
• W1867366263 hasRelatedWork W2903829653 @default.
• W1867366263 hasRelatedWork W4240643682 @default.
• W1867366263 hasVolume "93" @default.
• W1867366263 isParatext "false" @default.
• W1867366263 isRetracted "false" @default.
• W1867366263 magId "1867366263" @default.
• W1867366263 workType "article" @default.