FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1867508772> ?p ?o ?g. }

• W1867508772 endingPage "3338" @default.
• W1867508772 startingPage "3324" @default.
• W1867508772 abstract "The ability to mount effective secondary responses is a cardinal feature of memory CD8(+) T cells. An understanding of the factors that regulate the generation and recall capacities of memory T cells remains to be ascertained. Several cues indicate that two highly related cytokines, IL-2 and IL-15, share redundant functions in this process. To establish their combined roles in memory CD8(+) T-cell development, maintenance, and secondary responses, we compared the outcome of adoptively transferred IL2Rβ(+/-) or IL2Rβ(-/-) CD8(+) T cells after an acute viral infection in mice. Our results demonstrate that both IL-2 and IL-15 signals condition the differentiation of primary and secondary short-lived effector cells by altering the transcriptional network governing lineage choices. These two cytokines also regulate the homeostasis of the memory T-cell pool, with effector memory CD8(+) T cells being the most sensitive to these two interleukins. Noticeably, the inability to respond to both cytokines limits the proliferation and survival of primary and secondary effectors cells, whereas it does not preclude potent cytotoxic functions and viral control either initially or upon rechallenge. Globally, these results indicate that lack of IL-2 and IL-15 signaling modulates the CD8(+) T-cell differentiation program but does not impede adequate effector functions." @default.
• W1867508772 created "2016-06-24" @default.
• W1867508772 creator A5000732151 @default.
• W1867508772 creator A5001352788 @default.
• W1867508772 creator A5029057810 @default.
• W1867508772 creator A5029294518 @default.
• W1867508772 creator A5032817893 @default.
• W1867508772 creator A5040602234 @default.
• W1867508772 creator A5049678954 @default.
• W1867508772 date "2015-11-02" @default.
• W1867508772 modified "2023-10-16" @default.
• W1867508772 title "IL-2 and IL-15 regulate CD8⁺memory T-cell differentiation but are dispensable for protective recall responses" @default.
• W1867508772 cites W1482928030 @default.
• W1867508772 cites W1505467055 @default.
• W1867508772 cites W1507800008 @default.
• W1867508772 cites W1524005671 @default.
• W1867508772 cites W1544769291 @default.
• W1867508772 cites W1584891848 @default.
• W1867508772 cites W1781304070 @default.
• W1867508772 cites W1966073897 @default.
• W1867508772 cites W1967087194 @default.
• W1867508772 cites W1974494916 @default.
• W1867508772 cites W1974842026 @default.
• W1867508772 cites W1975682095 @default.
• W1867508772 cites W1976355501 @default.
• W1867508772 cites W1976714959 @default.
• W1867508772 cites W1976785514 @default.
• W1867508772 cites W1981318710 @default.
• W1867508772 cites W1982226677 @default.
• W1867508772 cites W1983067071 @default.
• W1867508772 cites W1984781939 @default.
• W1867508772 cites W1985294654 @default.
• W1867508772 cites W1990555844 @default.
• W1867508772 cites W2003959861 @default.
• W1867508772 cites W2005154465 @default.
• W1867508772 cites W2006932846 @default.
• W1867508772 cites W2015848791 @default.
• W1867508772 cites W2016804485 @default.
• W1867508772 cites W2025418275 @default.
• W1867508772 cites W2027132663 @default.
• W1867508772 cites W2030375564 @default.
• W1867508772 cites W2030512306 @default.
• W1867508772 cites W2035238198 @default.
• W1867508772 cites W2041061869 @default.
• W1867508772 cites W2041218370 @default.
• W1867508772 cites W2043793366 @default.
• W1867508772 cites W2049345643 @default.
• W1867508772 cites W2059431619 @default.
• W1867508772 cites W2064706357 @default.
• W1867508772 cites W2068046103 @default.
• W1867508772 cites W2068122289 @default.
• W1867508772 cites W2080196128 @default.
• W1867508772 cites W2096682152 @default.
• W1867508772 cites W2102950218 @default.
• W1867508772 cites W2106166533 @default.
• W1867508772 cites W2114263643 @default.
• W1867508772 cites W2118641214 @default.
• W1867508772 cites W2121211022 @default.
• W1867508772 cites W2122179332 @default.
• W1867508772 cites W2129860342 @default.
• W1867508772 cites W2134637336 @default.
• W1867508772 cites W2137564018 @default.
• W1867508772 cites W2143963240 @default.
• W1867508772 cites W2145369044 @default.
• W1867508772 cites W2148358987 @default.
• W1867508772 cites W2149099076 @default.
• W1867508772 cites W2150098469 @default.
• W1867508772 cites W2153511402 @default.
• W1867508772 cites W2154154640 @default.
• W1867508772 cites W2163001100 @default.
• W1867508772 cites W2165684303 @default.
• W1867508772 cites W2167829261 @default.
• W1867508772 cites W2293648610 @default.
• W1867508772 cites W4361772937 @default.
• W1867508772 cites W808919061 @default.
• W1867508772 doi "https://doi.org/10.1002/eji.201546000" @default.
• W1867508772 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26426795" @default.
• W1867508772 hasPublicationYear "2015" @default.
• W1867508772 type Work @default.
• W1867508772 sameAs 1867508772 @default.
• W1867508772 citedByCount "23" @default.
• W1867508772 countsByYear W18675087722016 @default.
• W1867508772 countsByYear W18675087722017 @default.
• W1867508772 countsByYear W18675087722018 @default.
• W1867508772 countsByYear W18675087722019 @default.
• W1867508772 countsByYear W18675087722020 @default.
• W1867508772 countsByYear W18675087722021 @default.
• W1867508772 countsByYear W18675087722022 @default.
• W1867508772 countsByYear W18675087722023 @default.
• W1867508772 crossrefType "journal-article" @default.
• W1867508772 hasAuthorship W1867508772A5000732151 @default.
• W1867508772 hasAuthorship W1867508772A5001352788 @default.
• W1867508772 hasAuthorship W1867508772A5029057810 @default.
• W1867508772 hasAuthorship W1867508772A5029294518 @default.
• W1867508772 hasAuthorship W1867508772A5032817893 @default.
• W1867508772 hasAuthorship W1867508772A5040602234 @default.
• W1867508772 hasAuthorship W1867508772A5049678954 @default.
• W1867508772 hasBestOaLocation W18675087721 @default.

• next