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- W1867536060 abstract "The current study was designed to characterize the anticancer effects of clotrimazole on human cutaneous melanoma cells.The v-raf murine sarcoma viral oncogene homolog B1 V600E mutant melanoma cell line A375 was used as an in vitro model. Characterization tools included analyses of cell viability, gene expression, cell-cycle progression, annexin V reactivity and internucleosomal DNA fragmentation.Clotrimazole induced cytotoxicity in A375 human melanoma cells without significant changes of human keratinocyte cell viability. Clotrimazole, at a concentration that approximates the inhibitory concentration 50% (IC50) value (i.e. 10 μM), reduced the expression of hexokinase type-II, induced cell-cycle arrest at G1-S phase transition, altered annexin V reactivity and induced DNA fragmentation without evidence of necrosis.The current study provides evidence of a remarkable pro-apoptotic effect by clotrimazole against human melanoma cells, with a different mechanism of action and timeline of the apoptosis-related events when compared to cisplatin." @default.
- W1867536060 created "2016-06-24" @default.
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- W1867536060 date "2015-07-01" @default.
- W1867536060 modified "2023-10-16" @default.
- W1867536060 title "Analysis of the Antitumor Activity of Clotrimazole on A375 Human Melanoma Cells." @default.
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