Matches in SemOpenAlex for { <https://semopenalex.org/work/W1867665313> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W1867665313 startingPage "3156" @default.
- W1867665313 abstract "Background The novel TLR-9 agonist CYT003-QbG10 (CYT003) has clinical activity in persistent allergic asthma thought to be mediated via inhibition of TH2 immune response. Aims This post-hoc analysis of a proof-of-concept randomised phase IIa study in mild-to-moderate controlled asthma tested the effect of CYT003 vs placebo on treatment response markers by TH2 status assessed by baseline blood eosinophil count (bEos). Methods 63 patients received 7 doses of CYT003 (n=33) or placebo (n=30) over 12 weeks, with controlled ICS withdrawal in the last 8 weeks. Findings were stratified by an approximate median split of bEos. Results Mean (SE) bEos were 0.087 (0.01) in the lower (≤0.1 cells/nL) and 0.310 (0.03) in the higher bEos group. In higher bEos, ACQ increased significantly (p=0.002) from baseline with placebo (n=17) compared with CYT003 (n=16). This effect was evident before ICS withdrawal but was more obvious after (figure). There was no significant ACQ difference in patients with lower bEos (n=13 [placebo] and n=17 [CYT003]). FeNO (p=0.041) and FEV 1 deteriorated significantly with placebo compared with CYT003 (p=0.006) in patients with higher, but not lower, bEos. Conclusions Efficacy of CYT003 was most obvious in patients with evidence of TH2 activation. The effect persisted during ICS withdrawal, consistent with an inhibitory effect on TH2 immune responses. These findings warrant further investigation." @default.
- W1867665313 created "2016-06-24" @default.
- W1867665313 creator A5036775943 @default.
- W1867665313 creator A5040644897 @default.
- W1867665313 creator A5069959810 @default.
- W1867665313 creator A5078489750 @default.
- W1867665313 creator A5082487198 @default.
- W1867665313 date "2013-09-01" @default.
- W1867665313 modified "2023-09-27" @default.
- W1867665313 title "Effect of baseline eosinophil count on response to CYT003-QbG10 in patients with persistent allergic asthma" @default.
- W1867665313 hasPublicationYear "2013" @default.
- W1867665313 type Work @default.
- W1867665313 sameAs 1867665313 @default.
- W1867665313 citedByCount "0" @default.
- W1867665313 crossrefType "journal-article" @default.
- W1867665313 hasAuthorship W1867665313A5036775943 @default.
- W1867665313 hasAuthorship W1867665313A5040644897 @default.
- W1867665313 hasAuthorship W1867665313A5069959810 @default.
- W1867665313 hasAuthorship W1867665313A5078489750 @default.
- W1867665313 hasAuthorship W1867665313A5082487198 @default.
- W1867665313 hasConcept C126322002 @default.
- W1867665313 hasConcept C142724271 @default.
- W1867665313 hasConcept C203014093 @default.
- W1867665313 hasConcept C204787440 @default.
- W1867665313 hasConcept C207480886 @default.
- W1867665313 hasConcept C27081682 @default.
- W1867665313 hasConcept C2776042228 @default.
- W1867665313 hasConcept C2777037409 @default.
- W1867665313 hasConcept C3017583242 @default.
- W1867665313 hasConcept C535046627 @default.
- W1867665313 hasConcept C67761136 @default.
- W1867665313 hasConcept C71924100 @default.
- W1867665313 hasConcept C8891405 @default.
- W1867665313 hasConcept C90924648 @default.
- W1867665313 hasConceptScore W1867665313C126322002 @default.
- W1867665313 hasConceptScore W1867665313C142724271 @default.
- W1867665313 hasConceptScore W1867665313C203014093 @default.
- W1867665313 hasConceptScore W1867665313C204787440 @default.
- W1867665313 hasConceptScore W1867665313C207480886 @default.
- W1867665313 hasConceptScore W1867665313C27081682 @default.
- W1867665313 hasConceptScore W1867665313C2776042228 @default.
- W1867665313 hasConceptScore W1867665313C2777037409 @default.
- W1867665313 hasConceptScore W1867665313C3017583242 @default.
- W1867665313 hasConceptScore W1867665313C535046627 @default.
- W1867665313 hasConceptScore W1867665313C67761136 @default.
- W1867665313 hasConceptScore W1867665313C71924100 @default.
- W1867665313 hasConceptScore W1867665313C8891405 @default.
- W1867665313 hasConceptScore W1867665313C90924648 @default.
- W1867665313 hasLocation W18676653131 @default.
- W1867665313 hasOpenAccess W1867665313 @default.
- W1867665313 hasPrimaryLocation W18676653131 @default.
- W1867665313 hasRelatedWork W1826554039 @default.
- W1867665313 hasRelatedWork W1920872890 @default.
- W1867665313 hasRelatedWork W2055143333 @default.
- W1867665313 hasRelatedWork W2097862836 @default.
- W1867665313 hasRelatedWork W2277114491 @default.
- W1867665313 hasRelatedWork W2327216852 @default.
- W1867665313 hasRelatedWork W2335752008 @default.
- W1867665313 hasRelatedWork W2371555284 @default.
- W1867665313 hasRelatedWork W2390968181 @default.
- W1867665313 hasRelatedWork W2393767209 @default.
- W1867665313 hasRelatedWork W2420157788 @default.
- W1867665313 hasRelatedWork W2516037051 @default.
- W1867665313 hasRelatedWork W2557049315 @default.
- W1867665313 hasRelatedWork W2585423421 @default.
- W1867665313 hasRelatedWork W2989041307 @default.
- W1867665313 hasRelatedWork W3029081484 @default.
- W1867665313 hasRelatedWork W3029555622 @default.
- W1867665313 hasRelatedWork W3030543437 @default.
- W1867665313 hasRelatedWork W3031905245 @default.
- W1867665313 hasRelatedWork W3184925237 @default.
- W1867665313 hasVolume "42" @default.
- W1867665313 isParatext "false" @default.
- W1867665313 isRetracted "false" @default.
- W1867665313 magId "1867665313" @default.
- W1867665313 workType "article" @default.