FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W186776021> ?p ?o ?g. }

• W186776021 endingPage "8" @default.
• W186776021 startingPage "31" @default.
• W186776021 abstract "To investigate the efficacy, safety and survival of tumour necrosis factor (TNF) α antagonists in patients with rheumatoid arthritis (RA).One hundred and fifty-one RA patients treated with TNF-α inhibitors during the time period 2000 to 2009 were studied. Kaplan-Meier statistic analysis was applied, in which discontinuation from anti-TNF-α therapy was used as the terminal event.Eighty-two patients received infliximab, 49 adalimumab and 20 etanercept: they were followed up over 7, 5 and 4 years, respectively. Anti-TNF-α therapy resulted in a rapid clinical improvement associated with a reduction in inflammatory markers in the first year of the treatment, which was sustained throughout the following years. Ninety (59.6%) patients were withdrawn during the observational period overall. The patients who discontinued infliximab, adalimumab and etanercept therapy were 55/82 (67.1%), 27/49 (55.1%) and 8/20 (40%) respectively. The main reasons for discontinuation were drug adverse events and inefficacy. According to Kaplan-Meier methods, the 'survival rate' of infliximab after the first year of treatment reached 82.9%, while after 7 years the proportion was 32.9%. With regard to adalimumab, after the first year of treatment its 'survival rate' was 83.7% and after 5 years it reached 44.9%. As far as etanercept is concerned, after the first year of treatment, the 'survival rate' reached 70% and after 4 years it remained 60%.TNF-α antagonists constitute an effective therapeutic option for patients with RA refractory to disease-modifying anti-rheumatic drugs. They demonstrate an acceptable safety profile. Their survival rate is high in the first years of treatment, while after the fifth year it decreases considerably." @default.
• W186776021 created "2016-06-24" @default.
• W186776021 creator A5002536319 @default.
• W186776021 creator A5025992165 @default.
• W186776021 creator A5057772222 @default.
• W186776021 creator A5061084566 @default.
• W186776021 creator A5064363682 @default.
• W186776021 date "2011-12-14" @default.
• W186776021 modified "2023-10-01" @default.
• W186776021 title "Survival of TNF-alpha antagonists in rheumatoid arthritis: a long-term study." @default.
• W186776021 cites W1596381381 @default.
• W186776021 cites W1833163659 @default.
• W186776021 cites W1874236485 @default.
• W186776021 cites W1898024773 @default.
• W186776021 cites W1909342577 @default.
• W186776021 cites W1977078113 @default.
• W186776021 cites W1979251453 @default.
• W186776021 cites W1988108320 @default.
• W186776021 cites W1994065448 @default.
• W186776021 cites W1996389186 @default.
• W186776021 cites W2009258522 @default.
• W186776021 cites W2015215846 @default.
• W186776021 cites W2017727377 @default.
• W186776021 cites W2017883234 @default.
• W186776021 cites W2038535814 @default.
• W186776021 cites W2051728683 @default.
• W186776021 cites W2062860760 @default.
• W186776021 cites W2079590652 @default.
• W186776021 cites W2080089273 @default.
• W186776021 cites W2101840353 @default.
• W186776021 cites W2102888997 @default.
• W186776021 cites W2109237866 @default.
• W186776021 cites W2110177517 @default.
• W186776021 cites W2111153776 @default.
• W186776021 cites W2112405467 @default.
• W186776021 cites W2119046820 @default.
• W186776021 cites W2122000071 @default.
• W186776021 cites W2125486296 @default.
• W186776021 cites W2126275861 @default.
• W186776021 cites W2129841863 @default.
• W186776021 cites W2133541603 @default.
• W186776021 cites W2145117068 @default.
• W186776021 cites W2152348310 @default.
• W186776021 cites W2153529903 @default.
• W186776021 cites W2161159725 @default.
• W186776021 cites W2168148602 @default.
• W186776021 cites W2263228148 @default.
• W186776021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22935246" @default.
• W186776021 hasPublicationYear "2011" @default.
• W186776021 type Work @default.
• W186776021 sameAs 186776021 @default.
• W186776021 citedByCount "20" @default.
• W186776021 countsByYear W1867760212012 @default.
• W186776021 countsByYear W1867760212013 @default.
• W186776021 countsByYear W1867760212014 @default.
• W186776021 countsByYear W1867760212015 @default.
• W186776021 countsByYear W1867760212016 @default.
• W186776021 countsByYear W1867760212018 @default.
• W186776021 countsByYear W1867760212019 @default.
• W186776021 countsByYear W1867760212022 @default.
• W186776021 crossrefType "journal-article" @default.
• W186776021 hasAuthorship W186776021A5002536319 @default.
• W186776021 hasAuthorship W186776021A5025992165 @default.
• W186776021 hasAuthorship W186776021A5057772222 @default.
• W186776021 hasAuthorship W186776021A5061084566 @default.
• W186776021 hasAuthorship W186776021A5064363682 @default.
• W186776021 hasConcept C10515644 @default.
• W186776021 hasConcept C126322002 @default.
• W186776021 hasConcept C141071460 @default.
• W186776021 hasConcept C17991360 @default.
• W186776021 hasConcept C197934379 @default.
• W186776021 hasConcept C2776283816 @default.
• W186776021 hasConcept C2777138892 @default.
• W186776021 hasConcept C2777226972 @default.
• W186776021 hasConcept C2777575956 @default.
• W186776021 hasConcept C2778715236 @default.
• W186776021 hasConcept C2780132546 @default.
• W186776021 hasConcept C71924100 @default.
• W186776021 hasConcept C90924648 @default.
• W186776021 hasConceptScore W186776021C10515644 @default.
• W186776021 hasConceptScore W186776021C126322002 @default.
• W186776021 hasConceptScore W186776021C141071460 @default.
• W186776021 hasConceptScore W186776021C17991360 @default.
• W186776021 hasConceptScore W186776021C197934379 @default.
• W186776021 hasConceptScore W186776021C2776283816 @default.
• W186776021 hasConceptScore W186776021C2777138892 @default.
• W186776021 hasConceptScore W186776021C2777226972 @default.
• W186776021 hasConceptScore W186776021C2777575956 @default.
• W186776021 hasConceptScore W186776021C2778715236 @default.
• W186776021 hasConceptScore W186776021C2780132546 @default.
• W186776021 hasConceptScore W186776021C71924100 @default.
• W186776021 hasConceptScore W186776021C90924648 @default.
• W186776021 hasIssue "1" @default.
• W186776021 hasLocation W1867760211 @default.
• W186776021 hasOpenAccess W186776021 @default.
• W186776021 hasPrimaryLocation W1867760211 @default.
• W186776021 hasRelatedWork W2003561232 @default.
• W186776021 hasRelatedWork W2015993259 @default.

• next