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- W186783670 abstract "Structure-based drug design efforts traditionally focused on development of enzyme inhibitors and receptor blockers. This strategy has been successfully applied to inhibit a number of enzymes relevant to hypertension including Angiotensin Converting enzyme (ACE) and Angiotensin receptor (AT). Despite the usefulness of frequently prescribed ACE inhibitors and AT blockers in reducing high blood pressure, these compounds are much less effective in prevent-ing and reverting hypertension-induced end-organ damage while side effects and development of resistance remain serious limitations to their use." @default.
- W186783670 created "2016-06-24" @default.
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- W186783670 date "2011-01-01" @default.
- W186783670 modified "2023-09-27" @default.
- W186783670 title "Small molecule activators of angiotensin-converting enzyme 2" @default.
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