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- W1867861530 endingPage "1117" @default.
- W1867861530 startingPage "1109" @default.
- W1867861530 abstract "Rabs are the largest family of small GTPases and are master regulators of membrane trafficking. Following activation by guanine‐nucleotide exchange factors (GEFs), each Rab binds a specific set of effector proteins that mediate the various downstream functions of that Rab. Then, with the help of GTPase ‐activating proteins, the Rab converts GTP to GDP , terminating its function. There are over 60 Rabs in humans and only a subset has been analyzed in any detail. Recently, Rab35 has emerged as a key regulator of cargo recycling at endosomes, with an additional role in regulation of the actin cytoskeleton. Here, we will focus on the regulation of Rab35 activity by the connecdenn/ DENND1 family of GEFs and the TBC1D10 / EPI64 family of GTPase ‐activating proteins. We will describe how analysis of these proteins, as well as a plethora of Rab35 effectors has provided insights into Rab35 function. Finally, we will describe how Rab35 provides a novel link between the Rab and Arf family of GTPases with implications for tumor formation and invasiveness ." @default.
- W1867861530 created "2016-06-24" @default.
- W1867861530 creator A5035139800 @default.
- W1867861530 creator A5073868341 @default.
- W1867861530 creator A5084725578 @default.
- W1867861530 date "2013-08-21" @default.
- W1867861530 modified "2023-10-18" @default.
- W1867861530 title "Rab35: GEFs, GAPs and Effectors" @default.
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- W1867861530 doi "https://doi.org/10.1111/tra.12096" @default.
- W1867861530 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23905989" @default.
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