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• W1867938510 abstract "Apolipoprotein (apo)A-I alone or as a component of high density lipoprotein particles has antiatherogenic properties. The age-dependent decline in abundance of this protein may underlie the higher risk for developing occlusive coronary artery disease (CAD) in older individuals. Similar to humans, expression of rat apoA-I also declines with age. Results in rats showed that levels of serum apoA-I protein, hepatic mRNA, and transcription of the gene were decreased to 39%, 18%, and 38%, respectively, in 180-day-old animals compared to those of newborn rats. These findings suggest that a nuclear mechanism(s) may account for the decline in apoA-I expression. Accordingly, we examined hepatic nuclear binding activity to four specific cis-acting elements of the rat apoA-I promoter. There were age-dependent changes of binding activity to two proximal sites, B and C, but not to the more distal elements, IRCE and A. Decreased B-site binding activity correlated with lower mRNA levels encoding the activator, HNF-3β. The age-dependent change in the pattern of binding to site C was due to a switch from the activator, HNF-4, to the repressor, ARP-1.In summary, the age-related decline in apoA-I expression may arise from a reduction in the activity of both cis-acting elements, B and C.—Nakamura, T., A. Fox-Robichaud, R. Kikkawa, A. Kashiwagi, H. Kojima, M. Fujimiya, and N. C. W. Wong. Transcription factors and age-related decline in apolipoprotein A-I expression. J. Lipid Res. 1999. 40: 1709–1718." @default.
• W1867938510 created "2016-06-24" @default.
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• W1867938510 date "1999-09-01" @default.
• W1867938510 modified "2023-10-03" @default.
• W1867938510 title "Transcription factors and age-related decline in apolipoprotein A-I expression" @default.
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• W1867938510 doi "https://doi.org/10.1016/s0022-2275(20)33418-0" @default.
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