FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1867960014> ?p ?o ?g. }

• W1867960014 endingPage "3518" @default.
• W1867960014 startingPage "3515" @default.
• W1867960014 abstract "The 26S proteasome, a multicatalytic enzyme complex, is the main intracellular proteolytic system involved in the degradation of ubiquitinated proteins. The ability of proteasome inhibitors to induce apoptosis has been exploited in the recent development of chemotherapeutic agents. Here, we show that inhibition of proteasome by MG132 blocks DNA damage-induced apoptosis. Blockage of apoptosis by MG132 correlates with p53 stabilization and upregulation of p21/WAF1, a p53 transcriptional target. Surprisingly, in the absence of MG132, robust apoptosis induced by a high dose of UV irradiation correlate with rapid p53 degradation. This is in sharp contrast to p53 stabilization when cells were exposed to lower levels of UV irradiation. Our findings highlight a scenario in which severe UV damage can induce rapid p53 degradation by the proteasome. Importantly, these data suggest that the 26S proteasome plays a key role in promoting apoptosis induced by high doses of UV irradiation." @default.
• W1867960014 created "2016-06-24" @default.
• W1867960014 creator A5051480897 @default.
• W1867960014 creator A5067533298 @default.
• W1867960014 creator A5083228843 @default.
• W1867960014 date "2011-10-15" @default.
• W1867960014 modified "2023-10-18" @default.
• W1867960014 title "MG132 inhibition of proteasome blocks high-dose UV irradiation-induced apoptosis" @default.
• W1867960014 cites W1650797637 @default.
• W1867960014 cites W1944289918 @default.
• W1867960014 cites W1966163762 @default.
• W1867960014 cites W1980830373 @default.
• W1867960014 cites W1988120143 @default.
• W1867960014 cites W1988508668 @default.
• W1867960014 cites W1989106135 @default.
• W1867960014 cites W1989404227 @default.
• W1867960014 cites W1999353132 @default.
• W1867960014 cites W2002191849 @default.
• W1867960014 cites W2008933923 @default.
• W1867960014 cites W2012513792 @default.
• W1867960014 cites W2023623233 @default.
• W1867960014 cites W2025722611 @default.
• W1867960014 cites W2034195501 @default.
• W1867960014 cites W2045470248 @default.
• W1867960014 cites W2050237470 @default.
• W1867960014 cites W2081145901 @default.
• W1867960014 cites W2081639435 @default.
• W1867960014 cites W2091456508 @default.
• W1867960014 cites W2122028337 @default.
• W1867960014 cites W2125963106 @default.
• W1867960014 cites W2158069617 @default.
• W1867960014 cites W2467795300 @default.
• W1867960014 cites W4250177299 @default.
• W1867960014 doi "https://doi.org/10.4161/cc.10.20.17789" @default.
• W1867960014 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3266179" @default.
• W1867960014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22031102" @default.
• W1867960014 hasPublicationYear "2011" @default.
• W1867960014 type Work @default.
• W1867960014 sameAs 1867960014 @default.
• W1867960014 citedByCount "18" @default.
• W1867960014 countsByYear W18679600142012 @default.
• W1867960014 countsByYear W18679600142014 @default.
• W1867960014 countsByYear W18679600142015 @default.
• W1867960014 countsByYear W18679600142016 @default.
• W1867960014 countsByYear W18679600142017 @default.
• W1867960014 countsByYear W18679600142019 @default.
• W1867960014 countsByYear W18679600142021 @default.
• W1867960014 countsByYear W18679600142022 @default.
• W1867960014 countsByYear W18679600142023 @default.
• W1867960014 crossrefType "journal-article" @default.
• W1867960014 hasAuthorship W1867960014A5051480897 @default.
• W1867960014 hasAuthorship W1867960014A5067533298 @default.
• W1867960014 hasAuthorship W1867960014A5083228843 @default.
• W1867960014 hasBestOaLocation W18679600141 @default.
• W1867960014 hasConcept C104317684 @default.
• W1867960014 hasConcept C127561419 @default.
• W1867960014 hasConcept C143425029 @default.
• W1867960014 hasConcept C181199279 @default.
• W1867960014 hasConcept C190283241 @default.
• W1867960014 hasConcept C25602115 @default.
• W1867960014 hasConcept C27740335 @default.
• W1867960014 hasConcept C2778367456 @default.
• W1867960014 hasConcept C2778506107 @default.
• W1867960014 hasConcept C2781307694 @default.
• W1867960014 hasConcept C2992195973 @default.
• W1867960014 hasConcept C552990157 @default.
• W1867960014 hasConcept C55493867 @default.
• W1867960014 hasConcept C79879829 @default.
• W1867960014 hasConcept C86803240 @default.
• W1867960014 hasConcept C95444343 @default.
• W1867960014 hasConceptScore W1867960014C104317684 @default.
• W1867960014 hasConceptScore W1867960014C127561419 @default.
• W1867960014 hasConceptScore W1867960014C143425029 @default.
• W1867960014 hasConceptScore W1867960014C181199279 @default.
• W1867960014 hasConceptScore W1867960014C190283241 @default.
• W1867960014 hasConceptScore W1867960014C25602115 @default.
• W1867960014 hasConceptScore W1867960014C27740335 @default.
• W1867960014 hasConceptScore W1867960014C2778367456 @default.
• W1867960014 hasConceptScore W1867960014C2778506107 @default.
• W1867960014 hasConceptScore W1867960014C2781307694 @default.
• W1867960014 hasConceptScore W1867960014C2992195973 @default.
• W1867960014 hasConceptScore W1867960014C552990157 @default.
• W1867960014 hasConceptScore W1867960014C55493867 @default.
• W1867960014 hasConceptScore W1867960014C79879829 @default.
• W1867960014 hasConceptScore W1867960014C86803240 @default.
• W1867960014 hasConceptScore W1867960014C95444343 @default.
• W1867960014 hasIssue "20" @default.
• W1867960014 hasLocation W18679600141 @default.
• W1867960014 hasLocation W18679600142 @default.
• W1867960014 hasLocation W18679600143 @default.
• W1867960014 hasLocation W18679600144 @default.
• W1867960014 hasOpenAccess W1867960014 @default.
• W1867960014 hasPrimaryLocation W18679600141 @default.
• W1867960014 hasRelatedWork W1974611887 @default.
• W1867960014 hasRelatedWork W2004614920 @default.
• W1867960014 hasRelatedWork W2050388757 @default.
• W1867960014 hasRelatedWork W2069347326 @default.
• W1867960014 hasRelatedWork W2139653729 @default.

• next