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- W1868144050 abstract "Nineteen healthy humans (2 men and 17 women) served as experimental subjects in 4 experiments using diets having different levels of leucine and also a valine-deficient diet. The effect of an excess intake of leucine, with and without addition of vitamin B-6, and the effect of a deficiency of valine on urinary excretions of N1-methylnicotinamide, N1-methyl-2-pyridone-5-carboxamide, nicotinic acid, quinolinic acid, and 5-hydroxyindole acetic acid, and on the level of plasma amino acids were investigated. There was no effect of leucine on the excretion of these metabolites, but a marked decrease in the plasma (or serum) valine level was observed. The same decrease was seen when a valine-deficient diet was fed." @default.
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- W1868144050 date "1975-10-01" @default.
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- W1868144050 title "Effects of Excess Intake of Leucine and Valine Deficiency on Tryptophan and Niacin Metabolites in Humans" @default.
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- W1868144050 doi "https://doi.org/10.1093/jn/105.10.1241" @default.
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