Matches in SemOpenAlex for { <https://semopenalex.org/work/W1868320626> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W1868320626 abstract "The excitation of longitudinal antral muscle by substance P (SP) involves both a myogenic and a cholinergic effect. To examine if these responses are mediated by different neurokinin receptors, we studied the mechanical response and the release of [3H]acetylcholine from antral muscle strips in response to SP, substance P methylester (SPME), neurokinin A (NKA), neurokinin B (NKB), and several non-mammalian tachykinins. All peptides studied showed a dose-dependent inotropic and chronotropic effect on spontaneous phasic contractions. This ionotropic effect in longitudinal muscle was partially atropine sensitive for SPME, SP, and NKB but not for NKA, whereas neither atropine nor tetrodotoxin had an effect in circular muscle. In longitudinal muscle, all three neurokinins were equipotent. In longitudinal muscle treated with atropine and in circular muscle, the rank order of potency for the inotropic response was NKA greater than NKB greater than SP greater than SPME. For the chronotropic response the rank order was SPME, SP greater than NKA greater than NKB. NKA, NKB, and SP caused a dose-dependent, tetrodotoxin-sensitive increase in [3H]acetylcholine release from strips preincubated with [3H]choline. NKA was significantly more potent to release [3H]acetylcholine than either NKB or SP. The stimulated release was inhibited by [D-Ala2,D-Met5]methionine enkephalinamide and the SP antagonist, spantide. These results are consistent with the hypothesis that NKA is the natural ligand mediating the myogenic inotropic response in both muscle layers and the cholinergic response in longitudinal muscle." @default.
- W1868320626 created "2016-06-24" @default.
- W1868320626 creator A5027806481 @default.
- W1868320626 creator A5036002302 @default.
- W1868320626 creator A5040496380 @default.
- W1868320626 creator A5058151859 @default.
- W1868320626 creator A5058259826 @default.
- W1868320626 date "1988-12-01" @default.
- W1868320626 modified "2023-09-23" @default.
- W1868320626 title "Characterization of the effects of neurokinins on canine antral muscle" @default.
- W1868320626 doi "https://doi.org/10.1152/ajpgi.1988.255.6.g779" @default.
- W1868320626 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2462362" @default.
- W1868320626 hasPublicationYear "1988" @default.
- W1868320626 type Work @default.
- W1868320626 sameAs 1868320626 @default.
- W1868320626 citedByCount "2" @default.
- W1868320626 crossrefType "journal-article" @default.
- W1868320626 hasAuthorship W1868320626A5027806481 @default.
- W1868320626 hasAuthorship W1868320626A5036002302 @default.
- W1868320626 hasAuthorship W1868320626A5040496380 @default.
- W1868320626 hasAuthorship W1868320626A5058151859 @default.
- W1868320626 hasAuthorship W1868320626A5058259826 @default.
- W1868320626 hasConcept C118303440 @default.
- W1868320626 hasConcept C126322002 @default.
- W1868320626 hasConcept C134018914 @default.
- W1868320626 hasConcept C170493617 @default.
- W1868320626 hasConcept C185592680 @default.
- W1868320626 hasConcept C22885893 @default.
- W1868320626 hasConcept C24998067 @default.
- W1868320626 hasConcept C2775859210 @default.
- W1868320626 hasConcept C2775910092 @default.
- W1868320626 hasConcept C2776050358 @default.
- W1868320626 hasConcept C2776533618 @default.
- W1868320626 hasConcept C2776741303 @default.
- W1868320626 hasConcept C2777056410 @default.
- W1868320626 hasConcept C2778988552 @default.
- W1868320626 hasConcept C2780660124 @default.
- W1868320626 hasConcept C2781359426 @default.
- W1868320626 hasConcept C33789571 @default.
- W1868320626 hasConcept C71924100 @default.
- W1868320626 hasConcept C86803240 @default.
- W1868320626 hasConceptScore W1868320626C118303440 @default.
- W1868320626 hasConceptScore W1868320626C126322002 @default.
- W1868320626 hasConceptScore W1868320626C134018914 @default.
- W1868320626 hasConceptScore W1868320626C170493617 @default.
- W1868320626 hasConceptScore W1868320626C185592680 @default.
- W1868320626 hasConceptScore W1868320626C22885893 @default.
- W1868320626 hasConceptScore W1868320626C24998067 @default.
- W1868320626 hasConceptScore W1868320626C2775859210 @default.
- W1868320626 hasConceptScore W1868320626C2775910092 @default.
- W1868320626 hasConceptScore W1868320626C2776050358 @default.
- W1868320626 hasConceptScore W1868320626C2776533618 @default.
- W1868320626 hasConceptScore W1868320626C2776741303 @default.
- W1868320626 hasConceptScore W1868320626C2777056410 @default.
- W1868320626 hasConceptScore W1868320626C2778988552 @default.
- W1868320626 hasConceptScore W1868320626C2780660124 @default.
- W1868320626 hasConceptScore W1868320626C2781359426 @default.
- W1868320626 hasConceptScore W1868320626C33789571 @default.
- W1868320626 hasConceptScore W1868320626C71924100 @default.
- W1868320626 hasConceptScore W1868320626C86803240 @default.
- W1868320626 hasLocation W18683206261 @default.
- W1868320626 hasLocation W18683206262 @default.
- W1868320626 hasOpenAccess W1868320626 @default.
- W1868320626 hasPrimaryLocation W18683206261 @default.
- W1868320626 hasRelatedWork W1868320626 @default.
- W1868320626 hasRelatedWork W1922743295 @default.
- W1868320626 hasRelatedWork W1950005168 @default.
- W1868320626 hasRelatedWork W1987298341 @default.
- W1868320626 hasRelatedWork W1987542540 @default.
- W1868320626 hasRelatedWork W2025024168 @default.
- W1868320626 hasRelatedWork W2054566209 @default.
- W1868320626 hasRelatedWork W2070803151 @default.
- W1868320626 hasRelatedWork W2172113265 @default.
- W1868320626 hasRelatedWork W2285334280 @default.
- W1868320626 isParatext "false" @default.
- W1868320626 isRetracted "false" @default.
- W1868320626 magId "1868320626" @default.
- W1868320626 workType "article" @default.