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- W1868339502 abstract "In French Guiana, the unique Coxiella burnetii circulating genotype 17 causes 24% of community-acquired pneumonia, the highest prevalence ever described. To explain this unusual virulence, we performed a comparative genomic analysis of strain Cb175, which was isolated from a patient from French Guiana. Cb175 has a greater number of mutations in genes involved in metabolism compared with the Nine Mile I strain. We found a 6105bp fragment missing in Cb175, which corresponds to the Type 1 secretion systems (T1SS) hlyCABD operon region. This deletion was detected by a specific qPCR in the 8 other strains available from this territory an in none of 298C.burnetii strains from other areas and other genotypes (8/8 vs 0/298, Fisher's exact test, p<0.0000001). Loss of genes implicated in secretion systems has been observed in other epidemic bacterial strains. Thus, the virulence of Cb175 may be linked to this genome reduction." @default.
- W1868339502 created "2016-06-24" @default.
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- W1868339502 date "2015-08-01" @default.
- W1868339502 modified "2023-10-18" @default.
- W1868339502 title "Loss of TSS1 in hypervirulent Coxiella burnetii 175, the causative agent of Q fever in French Guiana" @default.
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- W1868339502 doi "https://doi.org/10.1016/j.cimid.2015.04.003" @default.
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