FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1868617466> ?p ?o ?g. }

• W1868617466 abstract "We have reported that N-(phosphonacetyl)-L-aspartic acid (PALA) 1266 mg/m2 can safely be given 24 hours prior to the start of a 72-hour infusion of fluorouracil (FUra) and leucovorin (LV) at doses of 2000 and 500 mg/m2/day. Since inhibition of aspartate carbamoyltransferase (ACTase) activity was evident 4 hours post PALA, we wished to evaluate PALA given 1 hour prior to FUra. Further, we studied the toxicity and pharmacokinetics with FUra given by either fixed- or variable-rate infusion.Twenty-seven patients with gastrointestinal tract adenocarcinomas were treated with PALA 1266 mg/m2/15 min followed by a 72-hour infusion of FUra and LV (1750 & 500 mg/m2/day) given by fixed- or variable-rate (peak at 4:00 A.M.).Clinical toxicity was similar in two consecutive cycles in 17 patients receiving fixed- and variable-rate infusion at the same FUra dose. Overall, grade 3 stomatitis and hand-foot syndrome occurred in 12% and 4% patients receiving fixed- and in 16% and 10.5% of patients receiving variable-rate infusions. Six of 24 evaluable patients (25%) had a partial response. The profile of FUra plasma levels (Cp) over a 24-hour period during fixed- and variable-rate infusions were strikingly different, but the average Cp and area under the concentration-time curves were comparable. ACTase activity was significantly decreased at 4 and 24 hours after PALA (12% and 18% of baseline; P < 0.001), but enzyme activity had recovered to 40% by 72 hours.This regimen was active and well tolerated with similar toxicities with FUra given by either fixed- or variable rate infusion. PALA 1266 mg/m2 significantly inhibited ACTase activity for at least 24 hours." @default.
• W1868617466 created "2016-06-24" @default.
• W1868617466 creator A5028471294 @default.
• W1868617466 creator A5032312196 @default.
• W1868617466 creator A5045286901 @default.
• W1868617466 creator A5045440420 @default.
• W1868617466 creator A5056028528 @default.
• W1868617466 creator A5069843364 @default.
• W1868617466 creator A5077156722 @default.
• W1868617466 creator A5083018688 @default.
• W1868617466 creator A5088473266 @default.
• W1868617466 creator A5091801949 @default.
• W1868617466 date "2001-11-01" @default.
• W1868617466 modified "2023-09-26" @default.
• W1868617466 title "N-(phosphonacetyl)-l-aspartate and calcium leucovorin modulation of fluorouracil administered by constant rate and circadian pattern of infusion over 72 hours in metastatic gastrointestinal adenocarcinoma" @default.
• W1868617466 cites W1503102914 @default.
• W1868617466 cites W1589489802 @default.
• W1868617466 cites W1598009345 @default.
• W1868617466 cites W1867436544 @default.
• W1868617466 cites W1979300931 @default.
• W1868617466 cites W1992255836 @default.
• W1868617466 cites W1996167718 @default.
• W1868617466 cites W2025955761 @default.
• W1868617466 cites W2046506020 @default.
• W1868617466 cites W2088210473 @default.
• W1868617466 cites W2103588102 @default.
• W1868617466 cites W2107364108 @default.
• W1868617466 cites W2110509422 @default.
• W1868617466 cites W2114605359 @default.
• W1868617466 cites W2114975594 @default.
• W1868617466 cites W2115794606 @default.
• W1868617466 cites W2152486489 @default.
• W1868617466 cites W2165324981 @default.
• W1868617466 cites W2227311140 @default.
• W1868617466 cites W2234894755 @default.
• W1868617466 cites W2247895695 @default.
• W1868617466 cites W2257660895 @default.
• W1868617466 cites W2258295221 @default.
• W1868617466 cites W2419541415 @default.
• W1868617466 cites W2993254378 @default.
• W1868617466 doi "https://doi.org/10.1023/a:1013185125186" @default.
• W1868617466 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11822758" @default.
• W1868617466 hasPublicationYear "2001" @default.
• W1868617466 type Work @default.
• W1868617466 sameAs 1868617466 @default.
• W1868617466 citedByCount "1" @default.
• W1868617466 countsByYear W18686174662012 @default.
• W1868617466 crossrefType "journal-article" @default.
• W1868617466 hasAuthorship W1868617466A5028471294 @default.
• W1868617466 hasAuthorship W1868617466A5032312196 @default.
• W1868617466 hasAuthorship W1868617466A5045286901 @default.
• W1868617466 hasAuthorship W1868617466A5045440420 @default.
• W1868617466 hasAuthorship W1868617466A5056028528 @default.
• W1868617466 hasAuthorship W1868617466A5069843364 @default.
• W1868617466 hasAuthorship W1868617466A5077156722 @default.
• W1868617466 hasAuthorship W1868617466A5083018688 @default.
• W1868617466 hasAuthorship W1868617466A5088473266 @default.
• W1868617466 hasAuthorship W1868617466A5091801949 @default.
• W1868617466 hasBestOaLocation W18686174661 @default.
• W1868617466 hasConcept C126322002 @default.
• W1868617466 hasConcept C2776694085 @default.
• W1868617466 hasConcept C2780456651 @default.
• W1868617466 hasConcept C29730261 @default.
• W1868617466 hasConcept C42219234 @default.
• W1868617466 hasConcept C71924100 @default.
• W1868617466 hasConcept C90924648 @default.
• W1868617466 hasConceptScore W1868617466C126322002 @default.
• W1868617466 hasConceptScore W1868617466C2776694085 @default.
• W1868617466 hasConceptScore W1868617466C2780456651 @default.
• W1868617466 hasConceptScore W1868617466C29730261 @default.
• W1868617466 hasConceptScore W1868617466C42219234 @default.
• W1868617466 hasConceptScore W1868617466C71924100 @default.
• W1868617466 hasConceptScore W1868617466C90924648 @default.
• W1868617466 hasLocation W18686174661 @default.
• W1868617466 hasLocation W18686174662 @default.
• W1868617466 hasOpenAccess W1868617466 @default.
• W1868617466 hasPrimaryLocation W18686174661 @default.
• W1868617466 hasRelatedWork W1914083359 @default.
• W1868617466 hasRelatedWork W1984072600 @default.
• W1868617466 hasRelatedWork W2038293059 @default.
• W1868617466 hasRelatedWork W2039384311 @default.
• W1868617466 hasRelatedWork W2097666374 @default.
• W1868617466 hasRelatedWork W2100998189 @default.
• W1868617466 hasRelatedWork W2103207223 @default.
• W1868617466 hasRelatedWork W2107390900 @default.
• W1868617466 hasRelatedWork W2140611209 @default.
• W1868617466 hasRelatedWork W2206776658 @default.
• W1868617466 hasRelatedWork W2256607393 @default.
• W1868617466 hasRelatedWork W2327573666 @default.
• W1868617466 hasRelatedWork W2402143039 @default.
• W1868617466 hasRelatedWork W2402569892 @default.
• W1868617466 hasRelatedWork W2405372846 @default.
• W1868617466 hasRelatedWork W2415690480 @default.
• W1868617466 hasRelatedWork W2416864229 @default.
• W1868617466 hasRelatedWork W2428865517 @default.
• W1868617466 hasRelatedWork W2464419006 @default.
• W1868617466 hasRelatedWork W9584120 @default.
• W1868617466 isParatext "false" @default.
• W1868617466 isRetracted "false" @default.
• W1868617466 magId "1868617466" @default.

• next