Matches in SemOpenAlex for { <https://semopenalex.org/work/W1868688937> ?p ?o ?g. }
- W1868688937 abstract "We evaluated differences in cytokine responses and T-lymphocyte subsets following retroperitoneal laparoscopic and conventional open radical nephrectomies for localized renal cell carcinoma (RCC).A total of 62 patients with T(1)N(0)M(0) staged RCC were randomized to either retro-laparoscopic (n = 31) or open (n = 31) radical nephrectomy. Plasma levels of interleukin-1β (IL-1β), IL-6, and tumour necrosis factor-alpha (TNF-α) were measured separately by enzyme linked immunosorbent assay (ELISA) preoperatively and on postoperative days 1 and 5. Levels of CD3(+), CD4(+) and CD8(+) as well as the CD4(+):CD8(+) ratio were acquired by flow cytometry at the same time points.Levels of IL-1β, IL-6 and TNF-α increased significantly compared to preoperative values in both groups (p < 0.05) on postoperative day 1, and all the parameters in the open group were significantly higher than those in the retro-laparoscopy group (p < 0.05). On postoperative day 1, the levels of CD3(+) and CD4(+) and the CD4(+):CD8(+) ratio decreased markedly compared to preoperative values for both groups (p < 0.05). Elevations of the CD4(+):CD8(+) ratio in the retro-laparoscopy group (p < 0.05) and the CD8(+) level in the open group (p < 0.05) were observed when compared with the other group. On postoperative day 5, the levels of CD3(+) and CD4(+) and the CD4(+):CD8(+) ratio in the retro-laparoscopy group, as well as the level of CD8(+) in the open group, returned to about preoperative levels (p < 0.05). Follow-up ranged from 4 to 14 months postoperatively in all 62 patients with a 100% cancer-specific survival rate in both groups.Retroperitoneal laparoscopic radical nephrectomy is associated with the milder cytokine responses caused by trauma and inflammation and the better preserved distribution of T-lymphocytes." @default.
- W1868688937 created "2016-06-24" @default.
- W1868688937 creator A5002480533 @default.
- W1868688937 creator A5008703592 @default.
- W1868688937 creator A5030863883 @default.
- W1868688937 creator A5057041997 @default.
- W1868688937 creator A5063227954 @default.
- W1868688937 creator A5085712319 @default.
- W1868688937 date "2012-12-01" @default.
- W1868688937 modified "2023-09-27" @default.
- W1868688937 title "Early immune outcome of retroperitoneal laparoscopic radical nephrectomy for localized renal cell carcinoma: a prospective, randomized study." @default.
- W1868688937 cites W1512225597 @default.
- W1868688937 cites W1969356869 @default.
- W1868688937 cites W1972229497 @default.
- W1868688937 cites W1973478081 @default.
- W1868688937 cites W1973870414 @default.
- W1868688937 cites W1986808086 @default.
- W1868688937 cites W1987166621 @default.
- W1868688937 cites W1990171752 @default.
- W1868688937 cites W1994244808 @default.
- W1868688937 cites W2011885145 @default.
- W1868688937 cites W2013554663 @default.
- W1868688937 cites W2019285533 @default.
- W1868688937 cites W2022586549 @default.
- W1868688937 cites W2022814847 @default.
- W1868688937 cites W2027425045 @default.
- W1868688937 cites W2041471261 @default.
- W1868688937 cites W2048122282 @default.
- W1868688937 cites W2048910634 @default.
- W1868688937 cites W2056882163 @default.
- W1868688937 cites W2061141098 @default.
- W1868688937 cites W2079524383 @default.
- W1868688937 cites W2090569540 @default.
- W1868688937 cites W2094513896 @default.
- W1868688937 cites W2106940293 @default.
- W1868688937 cites W2112350068 @default.
- W1868688937 cites W2120997743 @default.
- W1868688937 cites W2138898868 @default.
- W1868688937 cites W2255548996 @default.
- W1868688937 cites W2320709439 @default.
- W1868688937 cites W2333156342 @default.
- W1868688937 cites W2409966131 @default.
- W1868688937 cites W263271174 @default.
- W1868688937 cites W2074907798 @default.
- W1868688937 doi "https://doi.org/10.5489/cuaj.11003" @default.
- W1868688937 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3529729" @default.
- W1868688937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22060731" @default.
- W1868688937 hasPublicationYear "2012" @default.
- W1868688937 type Work @default.
- W1868688937 sameAs 1868688937 @default.
- W1868688937 citedByCount "1" @default.
- W1868688937 countsByYear W18686889372012 @default.
- W1868688937 crossrefType "journal-article" @default.
- W1868688937 hasAuthorship W1868688937A5002480533 @default.
- W1868688937 hasAuthorship W1868688937A5008703592 @default.
- W1868688937 hasAuthorship W1868688937A5030863883 @default.
- W1868688937 hasAuthorship W1868688937A5057041997 @default.
- W1868688937 hasAuthorship W1868688937A5063227954 @default.
- W1868688937 hasAuthorship W1868688937A5085712319 @default.
- W1868688937 hasConcept C126322002 @default.
- W1868688937 hasConcept C126894567 @default.
- W1868688937 hasConcept C141071460 @default.
- W1868688937 hasConcept C167672396 @default.
- W1868688937 hasConcept C168563851 @default.
- W1868688937 hasConcept C203014093 @default.
- W1868688937 hasConcept C2777472916 @default.
- W1868688937 hasConcept C2777785397 @default.
- W1868688937 hasConcept C2780047204 @default.
- W1868688937 hasConcept C2780091579 @default.
- W1868688937 hasConcept C2780227381 @default.
- W1868688937 hasConcept C2780678043 @default.
- W1868688937 hasConcept C71924100 @default.
- W1868688937 hasConcept C8891405 @default.
- W1868688937 hasConcept C90924648 @default.
- W1868688937 hasConceptScore W1868688937C126322002 @default.
- W1868688937 hasConceptScore W1868688937C126894567 @default.
- W1868688937 hasConceptScore W1868688937C141071460 @default.
- W1868688937 hasConceptScore W1868688937C167672396 @default.
- W1868688937 hasConceptScore W1868688937C168563851 @default.
- W1868688937 hasConceptScore W1868688937C203014093 @default.
- W1868688937 hasConceptScore W1868688937C2777472916 @default.
- W1868688937 hasConceptScore W1868688937C2777785397 @default.
- W1868688937 hasConceptScore W1868688937C2780047204 @default.
- W1868688937 hasConceptScore W1868688937C2780091579 @default.
- W1868688937 hasConceptScore W1868688937C2780227381 @default.
- W1868688937 hasConceptScore W1868688937C2780678043 @default.
- W1868688937 hasConceptScore W1868688937C71924100 @default.
- W1868688937 hasConceptScore W1868688937C8891405 @default.
- W1868688937 hasConceptScore W1868688937C90924648 @default.
- W1868688937 hasLocation W18686889371 @default.
- W1868688937 hasOpenAccess W1868688937 @default.
- W1868688937 hasPrimaryLocation W18686889371 @default.
- W1868688937 hasRelatedWork W1980276814 @default.
- W1868688937 hasRelatedWork W2004535349 @default.
- W1868688937 hasRelatedWork W2053536948 @default.
- W1868688937 hasRelatedWork W2071780636 @default.
- W1868688937 hasRelatedWork W2173859769 @default.
- W1868688937 hasRelatedWork W2347809981 @default.
- W1868688937 hasRelatedWork W2352418552 @default.
- W1868688937 hasRelatedWork W2353962633 @default.