FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1868708604> ?p ?o ?g. }

• W1868708604 endingPage "1903" @default.
• W1868708604 startingPage "1894" @default.
• W1868708604 abstract "To gain entry into the target cell, Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV) uses its spike (S) protein S2 subunit to fuse with the plasma or endosomal membrane. Previous work identified a peptide derived from the heptad repeat (HR) 2 domain in S2 subunit, HR2P, which potently blocked MERS-CoV S protein-mediated membrane fusion. Here, we tested an HR2P analogue with improved pharmaceutical property, HR2P-M2, for its inhibitory activity against MERS-CoV infection in vitro and in vivo. HR2P-M2 was highly effective in inhibiting MERS-CoV S protein-mediated cell-cell fusion and infection by pseudoviruses expressing MERS-CoV S protein with or without mutation in the HR1 region. It interacted with the HR1 peptide to form stable α-helical complex and blocked six-helix bundle formation between the HR1 and HR2 domains in the viral S protein. Intranasally administered HR2P-M2 effectively protected adenovirus serotype-5-human dipeptidyl peptidase 4-transduced mice from infection by MERS-CoV strains with or without mutations in the HR1 region of S protein, with >1000-fold reduction of viral titers in lung, and the protection was enhanced by combining HR2P-M2 with interferon β. These results indicate that this combination regimen merits further development to prevent MERS in high-risk populations, including healthcare workers and patient family members, and to treat MERS-CoV-infected patients." @default.
• W1868708604 created "2016-06-24" @default.
• W1868708604 creator A5051474892 @default.
• W1868708604 creator A5053960511 @default.
• W1868708604 creator A5065582452 @default.
• W1868708604 creator A5069302796 @default.
• W1868708604 creator A5071443629 @default.
• W1868708604 creator A5073793359 @default.
• W1868708604 creator A5078895477 @default.
• W1868708604 date "2015-06-08" @default.
• W1868708604 modified "2023-10-10" @default.
• W1868708604 title "Protective Effect of Intranasal Regimens Containing Peptidic Middle East Respiratory Syndrome Coronavirus Fusion Inhibitor Against MERS-CoV Infection" @default.
• W1868708604 cites W1789264759 @default.
• W1868708604 cites W1965378596 @default.
• W1868708604 cites W1966504197 @default.
• W1868708604 cites W1977858698 @default.
• W1868708604 cites W1989452309 @default.
• W1868708604 cites W1993374993 @default.
• W1868708604 cites W1994478379 @default.
• W1868708604 cites W1995696847 @default.
• W1868708604 cites W2005780220 @default.
• W1868708604 cites W2013090907 @default.
• W1868708604 cites W2017191121 @default.
• W1868708604 cites W2017248106 @default.
• W1868708604 cites W2034462612 @default.
• W1868708604 cites W2035958898 @default.
• W1868708604 cites W2036017311 @default.
• W1868708604 cites W2036656105 @default.
• W1868708604 cites W2038063067 @default.
• W1868708604 cites W2045002682 @default.
• W1868708604 cites W2049975503 @default.
• W1868708604 cites W2075569835 @default.
• W1868708604 cites W2078121682 @default.
• W1868708604 cites W2080511680 @default.
• W1868708604 cites W2085739552 @default.
• W1868708604 cites W2091055028 @default.
• W1868708604 cites W2103562758 @default.
• W1868708604 cites W2106967530 @default.
• W1868708604 cites W2107053896 @default.
• W1868708604 cites W2119111857 @default.
• W1868708604 cites W2120967846 @default.
• W1868708604 cites W2122649536 @default.
• W1868708604 cites W2132040786 @default.
• W1868708604 cites W2132056320 @default.
• W1868708604 cites W2139603860 @default.
• W1868708604 cites W2154040053 @default.
• W1868708604 cites W2158592618 @default.
• W1868708604 cites W2161687688 @default.
• W1868708604 cites W2166867592 @default.
• W1868708604 cites W2171353131 @default.
• W1868708604 cites W311927316 @default.
• W1868708604 cites W4237410627 @default.
• W1868708604 doi "https://doi.org/10.1093/infdis/jiv325" @default.
• W1868708604 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4655857" @default.
• W1868708604 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26164863" @default.
• W1868708604 hasPublicationYear "2015" @default.
• W1868708604 type Work @default.
• W1868708604 sameAs 1868708604 @default.
• W1868708604 citedByCount "82" @default.
• W1868708604 countsByYear W18687086042015 @default.
• W1868708604 countsByYear W18687086042016 @default.
• W1868708604 countsByYear W18687086042017 @default.
• W1868708604 countsByYear W18687086042018 @default.
• W1868708604 countsByYear W18687086042019 @default.
• W1868708604 countsByYear W18687086042020 @default.
• W1868708604 countsByYear W18687086042021 @default.
• W1868708604 countsByYear W18687086042022 @default.
• W1868708604 countsByYear W18687086042023 @default.
• W1868708604 crossrefType "journal-article" @default.
• W1868708604 hasAuthorship W1868708604A5051474892 @default.
• W1868708604 hasAuthorship W1868708604A5053960511 @default.
• W1868708604 hasAuthorship W1868708604A5065582452 @default.
• W1868708604 hasAuthorship W1868708604A5069302796 @default.
• W1868708604 hasAuthorship W1868708604A5071443629 @default.
• W1868708604 hasAuthorship W1868708604A5073793359 @default.
• W1868708604 hasAuthorship W1868708604A5078895477 @default.
• W1868708604 hasBestOaLocation W18687086041 @default.
• W1868708604 hasConcept C104317684 @default.
• W1868708604 hasConcept C122146531 @default.
• W1868708604 hasConcept C140704245 @default.
• W1868708604 hasConcept C142724271 @default.
• W1868708604 hasConcept C159047783 @default.
• W1868708604 hasConcept C167625842 @default.
• W1868708604 hasConcept C2522874641 @default.
• W1868708604 hasConcept C2776525042 @default.
• W1868708604 hasConcept C2777691041 @default.
• W1868708604 hasConcept C2779134260 @default.
• W1868708604 hasConcept C3008058167 @default.
• W1868708604 hasConcept C524204448 @default.
• W1868708604 hasConcept C55493867 @default.
• W1868708604 hasConcept C58475186 @default.
• W1868708604 hasConcept C71924100 @default.
• W1868708604 hasConcept C86803240 @default.
• W1868708604 hasConceptScore W1868708604C104317684 @default.
• W1868708604 hasConceptScore W1868708604C122146531 @default.
• W1868708604 hasConceptScore W1868708604C140704245 @default.
• W1868708604 hasConceptScore W1868708604C142724271 @default.
• W1868708604 hasConceptScore W1868708604C159047783 @default.

• next