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• W1868808302 abstract "Dietary cholesterol absorption was studied in patients with either mild (n = 23) or severe (n = 12) liver cirrhosis in relation to both total and individual bile acid pool size. Cholesterol absorption was significantly reduced in both groups of patients, and it was inversely related (r = -0.68; p less than 0.001) to the severity of the disease. Total, cholic acid, and deoxycholic acid p ool sizes were significantly reduced in cirrhosis, and a correlation was found between cholesterol absorption and cholic acid pool size (r = 0.78; p less than 0.001). In 5 patients, cholesterol absorption and bile acid pool size were estimated both before and after treatment with cholic acid (15 mg/kg/day) plus ampicillin (2 g/day). The treatment was followed by a mean threefold increase of cholic acid pool and by a sharp enhancement of cholesterol absorption in each patient. In conclusion, cholesterol absorption is often impaired in cirrhosis and is related to the severity of the disease. The correlation between cholic acid pool and cholesterol absorption and the constant increase of the absorption values after cholic acid pool expansion suggest that the size of cholic acid pool may be considered as an important factor in the regulation of cholesterol absorption." @default.
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• W1868808302 date "1981-06-01" @default.
• W1868808302 modified "2023-10-14" @default.
• W1868808302 title "Cholesterol absorption in cirrhosis: The role of total and individual bile acid pool size" @default.
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• W1868808302 doi "https://doi.org/10.1016/0016-5085(81)90253-5" @default.
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