FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1868834139> ?p ?o ?g. }

• W1868834139 endingPage "2185" @default.
• W1868834139 startingPage "2179" @default.
• W1868834139 abstract "Recent identification in bone of transporters, receptors, and components of synaptic signaling suggests a role for glutamate in the skeleton. We investigated effects of glutamate and its antagonist MK801 on osteoclasts in vitro. Glutamate applied to patch clamped osteoclasts induced significant increases in whole-cell membrane currents (P<0.01) in the presence of the coagonist glycine. Agonist-elicited currents were significantly decreased after application of MK801 (100 µM, P<0.01), butMK801 had no effect on actin ring formation necessary for osteoclast polarization, attachment, and resorption. In cocultures of bone marrow cells and osteoblasts in which osteoclasts develop, MK801 inhibited osteoclast differentiation and reduced resorption of pits in dentine (3 to 100 µM; P<0.001). MK801 added early in the culture (for as little as 2–4 days) was as effective as addition for the entire culture period. Addition of MK801 for any time after day 7 of culture was ineffective in reducing osteoclast activity. Using rat and rabbit mature osteoclasts cultured on dentine or explants of mouse calvariae prelabeled with 45Ca, we could not detect significant effects of MK801 on osteoclastic resorption. These data show clearly that glutamate receptor function is critical during osteoclastogenesis and suggest that glutamate is less important in regulating mature osteoclast activity.—Peet, N. M., Grabowski, P. S., Laketić-Ljubojević, I., Skerry, T. M. The glutamate receptor antagonist MK801 modulates bone resorption in vitro by a mechanism predominantly involving osteoclast differentiation. FASEB J. 13, 2179–2185 (1999)" @default.
• W1868834139 created "2016-06-24" @default.
• W1868834139 creator A5025060458 @default.
• W1868834139 creator A5044415925 @default.
• W1868834139 creator A5064265315 @default.
• W1868834139 creator A5085565282 @default.
• W1868834139 date "1999-12-01" @default.
• W1868834139 modified "2023-10-11" @default.
• W1868834139 title "The glutamate receptor antagonist MK801 modulates bone resorption<i>in vitro</i>by a mechanism predominantly involving osteoclast differentiation" @default.
• W1868834139 cites W1524901037 @default.
• W1868834139 cites W1965248309 @default.
• W1868834139 cites W1966198985 @default.
• W1868834139 cites W1977553486 @default.
• W1868834139 cites W1982749890 @default.
• W1868834139 cites W1996208391 @default.
• W1868834139 cites W1997119884 @default.
• W1868834139 cites W1997937617 @default.
• W1868834139 cites W2001294282 @default.
• W1868834139 cites W2005297452 @default.
• W1868834139 cites W2009951113 @default.
• W1868834139 cites W2012706480 @default.
• W1868834139 cites W2019297438 @default.
• W1868834139 cites W2027173748 @default.
• W1868834139 cites W2033801664 @default.
• W1868834139 cites W2035339470 @default.
• W1868834139 cites W2040107240 @default.
• W1868834139 cites W2044012909 @default.
• W1868834139 cites W2045707567 @default.
• W1868834139 cites W2048976632 @default.
• W1868834139 cites W2062191082 @default.
• W1868834139 cites W2062207135 @default.
• W1868834139 cites W2068800704 @default.
• W1868834139 cites W2073566150 @default.
• W1868834139 cites W2110689626 @default.
• W1868834139 cites W2120699640 @default.
• W1868834139 cites W2129108032 @default.
• W1868834139 cites W2139996507 @default.
• W1868834139 cites W2170247538 @default.
• W1868834139 cites W2340377903 @default.
• W1868834139 cites W4298824231 @default.
• W1868834139 cites W950716417 @default.
• W1868834139 doi "https://doi.org/10.1096/fasebj.13.15.2179" @default.
• W1868834139 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10593865" @default.
• W1868834139 hasPublicationYear "1999" @default.
• W1868834139 type Work @default.
• W1868834139 sameAs 1868834139 @default.
• W1868834139 citedByCount "103" @default.
• W1868834139 countsByYear W18688341392012 @default.
• W1868834139 countsByYear W18688341392013 @default.
• W1868834139 countsByYear W18688341392014 @default.
• W1868834139 countsByYear W18688341392015 @default.
• W1868834139 countsByYear W18688341392017 @default.
• W1868834139 countsByYear W18688341392018 @default.
• W1868834139 countsByYear W18688341392020 @default.
• W1868834139 countsByYear W18688341392021 @default.
• W1868834139 countsByYear W18688341392022 @default.
• W1868834139 countsByYear W18688341392023 @default.
• W1868834139 crossrefType "journal-article" @default.
• W1868834139 hasAuthorship W1868834139A5025060458 @default.
• W1868834139 hasAuthorship W1868834139A5044415925 @default.
• W1868834139 hasAuthorship W1868834139A5064265315 @default.
• W1868834139 hasAuthorship W1868834139A5085565282 @default.
• W1868834139 hasBestOaLocation W18688341391 @default.
• W1868834139 hasConcept C126322002 @default.
• W1868834139 hasConcept C134018914 @default.
• W1868834139 hasConcept C146562846 @default.
• W1868834139 hasConcept C170493617 @default.
• W1868834139 hasConcept C185592680 @default.
• W1868834139 hasConcept C2776033226 @default.
• W1868834139 hasConcept C2778938600 @default.
• W1868834139 hasConcept C2779428903 @default.
• W1868834139 hasConcept C55493867 @default.
• W1868834139 hasConcept C61174792 @default.
• W1868834139 hasConcept C67018056 @default.
• W1868834139 hasConcept C673006 @default.
• W1868834139 hasConcept C71924100 @default.
• W1868834139 hasConcept C86803240 @default.
• W1868834139 hasConcept C88045685 @default.
• W1868834139 hasConcept C95444343 @default.
• W1868834139 hasConceptScore W1868834139C126322002 @default.
• W1868834139 hasConceptScore W1868834139C134018914 @default.
• W1868834139 hasConceptScore W1868834139C146562846 @default.
• W1868834139 hasConceptScore W1868834139C170493617 @default.
• W1868834139 hasConceptScore W1868834139C185592680 @default.
• W1868834139 hasConceptScore W1868834139C2776033226 @default.
• W1868834139 hasConceptScore W1868834139C2778938600 @default.
• W1868834139 hasConceptScore W1868834139C2779428903 @default.
• W1868834139 hasConceptScore W1868834139C55493867 @default.
• W1868834139 hasConceptScore W1868834139C61174792 @default.
• W1868834139 hasConceptScore W1868834139C67018056 @default.
• W1868834139 hasConceptScore W1868834139C673006 @default.
• W1868834139 hasConceptScore W1868834139C71924100 @default.
• W1868834139 hasConceptScore W1868834139C86803240 @default.
• W1868834139 hasConceptScore W1868834139C88045685 @default.
• W1868834139 hasConceptScore W1868834139C95444343 @default.
• W1868834139 hasIssue "15" @default.
• W1868834139 hasLocation W18688341391 @default.
• W1868834139 hasLocation W18688341392 @default.

• next