FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1868962904> ?p ?o ?g. }

• W1868962904 abstract "Metastasis is a leading cause of cancer-related deaths. Carcinoma generally initiates at a specific organ as a primary tumor, but eventually metastasizes and forms tumor sites in other organs. In this report, we developed a mathematical model of cancer progression with alterations in metastasis-related genes. In cases in which tumor cells acquire metastatic ability through two steps of genetic alterations, we derive formulas for the probability, the expected number, and the distribution of the number of metastases. Moreover, we investigate practical pancreatic cancer disease progression in cases in which both one and two steps of genetic alterations are responsible for metastatic formation. Importantly, we derive a mathematical formula for the survival outcome validated using clinical data as well as direct simulations. Our model provides theoretical insights into how invisible metastases distribute upon diagnosis with respect to growth rates, (epi)genetic alteration rates, metastatic rate, and detection size. Prediction of survival outcome using the formula is of clinical importance in terms of determining therapeutic strategies." @default.
• W1868962904 created "2016-06-24" @default.
• W1868962904 creator A5000147539 @default.
• W1868962904 creator A5079780948 @default.
• W1868962904 creator A5082260162 @default.
• W1868962904 date "2015-10-30" @default.
• W1868962904 modified "2023-09-24" @default.
• W1868962904 title "The evolution of tumor metastasis during clonal expansion with alterations in metastasis driver genes" @default.
• W1868962904 cites W1533936180 @default.
• W1868962904 cites W1909781489 @default.
• W1868962904 cites W1967135832 @default.
• W1868962904 cites W1968549563 @default.
• W1868962904 cites W1969765652 @default.
• W1868962904 cites W1978515980 @default.
• W1868962904 cites W2009863423 @default.
• W1868962904 cites W2012403555 @default.
• W1868962904 cites W2016170301 @default.
• W1868962904 cites W2021548785 @default.
• W1868962904 cites W2022233074 @default.
• W1868962904 cites W2033224863 @default.
• W1868962904 cites W2034125992 @default.
• W1868962904 cites W2035235278 @default.
• W1868962904 cites W2042321087 @default.
• W1868962904 cites W2045373833 @default.
• W1868962904 cites W2050089891 @default.
• W1868962904 cites W2064165635 @default.
• W1868962904 cites W2066330900 @default.
• W1868962904 cites W2067420088 @default.
• W1868962904 cites W2071314305 @default.
• W1868962904 cites W2077393203 @default.
• W1868962904 cites W2083452953 @default.
• W1868962904 cites W2093921289 @default.
• W1868962904 cites W2095595785 @default.
• W1868962904 cites W2095641625 @default.
• W1868962904 cites W2101446591 @default.
• W1868962904 cites W2133063342 @default.
• W1868962904 cites W2144744111 @default.
• W1868962904 cites W2150550712 @default.
• W1868962904 cites W2165948908 @default.
• W1868962904 cites W2185791496 @default.
• W1868962904 cites W2317459595 @default.
• W1868962904 cites W3101634756 @default.
• W1868962904 doi "https://doi.org/10.1038/srep15886" @default.
• W1868962904 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4626809" @default.
• W1868962904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26515895" @default.
• W1868962904 hasPublicationYear "2015" @default.
• W1868962904 type Work @default.
• W1868962904 sameAs 1868962904 @default.
• W1868962904 citedByCount "14" @default.
• W1868962904 countsByYear W18689629042016 @default.
• W1868962904 countsByYear W18689629042017 @default.
• W1868962904 countsByYear W18689629042018 @default.
• W1868962904 countsByYear W18689629042019 @default.
• W1868962904 countsByYear W18689629042020 @default.
• W1868962904 countsByYear W18689629042021 @default.
• W1868962904 countsByYear W18689629042023 @default.
• W1868962904 crossrefType "journal-article" @default.
• W1868962904 hasAuthorship W1868962904A5000147539 @default.
• W1868962904 hasAuthorship W1868962904A5079780948 @default.
• W1868962904 hasAuthorship W1868962904A5082260162 @default.
• W1868962904 hasBestOaLocation W18689629041 @default.
• W1868962904 hasConcept C104317684 @default.
• W1868962904 hasConcept C121608353 @default.
• W1868962904 hasConcept C126322002 @default.
• W1868962904 hasConcept C142724271 @default.
• W1868962904 hasConcept C143998085 @default.
• W1868962904 hasConcept C2779013556 @default.
• W1868962904 hasConcept C2779134260 @default.
• W1868962904 hasConcept C2779256057 @default.
• W1868962904 hasConcept C2780210213 @default.
• W1868962904 hasConcept C2780283643 @default.
• W1868962904 hasConcept C2992691968 @default.
• W1868962904 hasConcept C502942594 @default.
• W1868962904 hasConcept C54355233 @default.
• W1868962904 hasConcept C60644358 @default.
• W1868962904 hasConcept C71924100 @default.
• W1868962904 hasConcept C86803240 @default.
• W1868962904 hasConceptScore W1868962904C104317684 @default.
• W1868962904 hasConceptScore W1868962904C121608353 @default.
• W1868962904 hasConceptScore W1868962904C126322002 @default.
• W1868962904 hasConceptScore W1868962904C142724271 @default.
• W1868962904 hasConceptScore W1868962904C143998085 @default.
• W1868962904 hasConceptScore W1868962904C2779013556 @default.
• W1868962904 hasConceptScore W1868962904C2779134260 @default.
• W1868962904 hasConceptScore W1868962904C2779256057 @default.
• W1868962904 hasConceptScore W1868962904C2780210213 @default.
• W1868962904 hasConceptScore W1868962904C2780283643 @default.
• W1868962904 hasConceptScore W1868962904C2992691968 @default.
• W1868962904 hasConceptScore W1868962904C502942594 @default.
• W1868962904 hasConceptScore W1868962904C54355233 @default.
• W1868962904 hasConceptScore W1868962904C60644358 @default.
• W1868962904 hasConceptScore W1868962904C71924100 @default.
• W1868962904 hasConceptScore W1868962904C86803240 @default.
• W1868962904 hasIssue "1" @default.
• W1868962904 hasLocation W18689629041 @default.
• W1868962904 hasLocation W18689629042 @default.
• W1868962904 hasLocation W18689629043 @default.
• W1868962904 hasLocation W18689629044 @default.
• W1868962904 hasOpenAccess W1868962904 @default.
• W1868962904 hasPrimaryLocation W18689629041 @default.

• next