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• W1869057116 abstract "α-Klotho has emerged as a powerful regulator of the aging process. To date, the expression profile of α-Klotho in human tissues is unknown, and its existence in some human tissue types is subject to much controversy.This is the first study to characterize systemwide tissue expression of transmembrane α-Klotho in humans. We have employed next-generation targeted proteomic analysis using parallel reaction monitoring in parallel with conventional antibody-based methods to determine the expression and spatial distribution of human α-Klotho expression in health.The distribution of α-Klotho in human tissues from various organ systems, including arterial, epithelial, endocrine, reproductive, and neuronal tissues, was first identified by immunohistochemistry. Kidney tissues showed strong α-Klotho expression, whereas liver did not reveal a detectable signal. These results were next confirmed by Western blotting of both whole tissues and primary cells. To validate our antibody-based results, α-Klotho-expressing tissues were subjected to parallel reaction monitoring mass spectrometry (data deposited at ProteomeXchange, PXD002775) identifying peptides specific for the full-length, transmembrane α-Klotho isoform.The data presented confirm α-Klotho expression in the kidney tubule and in the artery and provide evidence of α-Klotho expression across organ systems and cell types that has not previously been described in humans." @default.
• W1869057116 created "2016-06-24" @default.
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• W1869057116 date "2015-10-01" @default.
• W1869057116 modified "2023-10-12" @default.
• W1869057116 title "α-Klotho Expression in Human Tissues" @default.
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• W1869057116 doi "https://doi.org/10.1210/jc.2015-1800" @default.
• W1869057116 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4596032" @default.
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