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- W1869080905 abstract "Nicotine is the most potent psychoactive agent in tobacco, and many studies indicate that people adjust their tobacco use in an attempt to carefully titrate their plasma nicotine levels. Furthermore, pretreatment with the nicotinic receptor antagonist, mecamylamine, results in an increase in tobacco use. In addition, several studies have demonstrated that people differ in sensitivity to nicotine. The chapter discusses the role of genetic factors in regulating first dose sensitivity to nicotine and the development of tolerance to nicotine. The young males from families with a positive history for alcoholism are less affected by alcohol, both behaviorally and physiologically (prolactin and cortisol release), than are young males from families that do not have a history of alcoholism. Alternatively, it may be that those individuals who develop tolerance to the actions of nicotine are more likely to persist in using tobacco; i.e. smokers are those individuals who develop tolerance to the noxious actions of nicotine thereby uncovering the reinforcing actions. Receptor changes are more related to the development of dependence on nicotine. Analysis of this potential role will require the development of adequate methods of quantifying a nicotine withdrawal syndrome, if it exists, in the mouse." @default.
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- W1869080905 date "1989-01-01" @default.
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- W1869080905 title "Chronic nicotine exposure and brain nicotinic receptors--influence of genetic factors." @default.
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